Abstract
In this work, stable overexpression of peroxiredoxin VI was generated in WI-38 human diploid fibroblasts using a retrovirus-mediated transfection system. Estimation of cell survival showed that peroxiredoxin VI provides a significant protection against tert-butylhydroperoxide- or UVB-caused cytotoxicity. No protection was found against ethanol- or H2O2-caused cytotoxicity. These effects are correlated with the known functions of Prx VI.
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Dierick, JF., Wenders, F., Chainiaux, F. et al. Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB. Biogerontology 4, 125–131 (2003). https://doi.org/10.1023/A:1024154024602
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DOI: https://doi.org/10.1023/A:1024154024602