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Brachyurins, Serine Collagenolytic Enzymes from Crabs

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Abstract

The properties of brachyurins, proteolytic enzymes belonging to a new subfamily of chymotrypsin-like proteases, are considered. These enzymes, found in various species of crustacean, exhibit mixed substrate specificity and a marked collagenolytic activity. The enzymatic and physicochemical properties of brachyurins I and their primary and spatial structures are discussed in detail. A separate chapter is devoted to the preparations of collagenases from the hepatopancreas of king crab: their action on the damaged skin and use in medicine.

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References

  1. Stryer, L., Biochemistry, chapter 9, 1981. Translated under the title Biokhimiya, Moscow: Mir, 1984, vol. 1, pp. 179–197.

    Google Scholar 

  2. Bornstein, P. and Traub, W., The Chemistry and Biology of Collagen: The Proteins, New York: Academic, 1979, pp. 411–632.

    Google Scholar 

  3. Barret, A.J., Rawlings, N.D., and Woessner, J.F., Handbook of Proteolytic Enzymes, New York: Academic, 1998.

    Google Scholar 

  4. DeVillez, E.J. and Buschlen, K., Comp. Biochem. Physiol., A: Comp. Physiol., 1967, vol. 21, pp. 541–546.

    Google Scholar 

  5. Eisen, A.Z. and Jeffrey, J.J., Biochim. Biophys. Acta, 1969, vol. 191, pp. 517–526.

    Google Scholar 

  6. Eisen, A.Z., Henderson, K.O., Jeffrey, J.J., and Bradshaw, R.A., Biochemistry, 1973, vol. 12, pp. 1814–1822.

    Google Scholar 

  7. Zwilling, R., Pfleiderer, G., Sonneborn, H., Kraft, V., and Stucky, I., Comp. Biochem. Physiol., A: Comp. Physiol., 1969, vol. 28, pp. 1275–1287.

    Google Scholar 

  8. Gates, R.J. and Travis, J., Biochemistry, 1969, vol. 8, pp. 4483–4489.

    Google Scholar 

  9. Turkuiewicz, M., Galas, E., and Kalinowska, H., Comp. Biochem. Physiol., B: Comp. Biochem., 1991, vol. 99, pp. 359–371.

    Google Scholar 

  10. Grant, G.A., Sacchettini, J.C., and Welgus, H.G., Biochemistry, 1983, vol. 22, pp. 2228–2233.

    Google Scholar 

  11. Klimova, O.A., Borukhov, S.I., Solovyeva, N.I., Balaevskaya, T.O., and Strongin, A., Biochem. Biophys. Res. Commun., 1990, vol. 166, pp. 1411–1420.

    Google Scholar 

  12. Klimova, O.A., Vedishcheva, I., and Strongin, A.Ya., Dokl. AN SSSR, 1991, vol. 317, pp. 482–484.

    Google Scholar 

  13. Sakharov, I.Yu., Litvin, F.E., Artyukov, A.A., and Kofanova, N.N., Biokhimiya, 1988, vol. 53, pp. 1844–1849.

    Google Scholar 

  14. Sakharov, I.Yu., Litvin, F.E., and Artyukov, A.A., Biokhimiya (Moscow), 1992, vol. 57, pp. 40–45.

    Google Scholar 

  15. Rudenskaya, G.N., Isaev, V.A., Stepanov, V.M., Dunaevskii, Ya.E., Baratova, L.A., Kalebina, T.S., and Nurminskaya, M.V., Biokhimiya (Moscow), 1996, vol. 61, pp. 1119–1132.

    Google Scholar 

  16. Titani, K., Sasagawa, T., Woodbury, R.G., Ericsson, L.H., Dorsam, H., Kraemer, M., Neurath, H., and Zwilling, R., Biochemistry, 1983, vol. 22, pp. 1459–1465.

    Google Scholar 

  17. Lu, P.J., Liu, H.C., and Tsai, I.H., Biol. Chem. Hoppe-Seyler, 1990, vol. 371, pp. 851–859.

    Google Scholar 

  18. Tsai, I.H., Chuang, K.I., and Chuang, J.L., Comp. Biochem. Physiol., B: Comp. Biochem., 1986, vol. 85, pp. 235–239.

    Google Scholar 

  19. Tsai, I.H., Lu, P.Y., and Chuang, J.L., Biochim. Biophys. Acta, 1991, vol. 1080, pp. 59–67.

    Google Scholar 

  20. van Wormhoudt, A., Le Chevalier, P., and Sellos, D., Comp. Biochem. Physiol., B: Comp. Biochem., 1992, vol. 103.

  21. Klein, B., Le, M.G., Sellos, D., and van Wormhoudt, A., Int. J. Biochem., Cell Biol., 1996, vol. 28, pp. 551–563.

    Google Scholar 

  22. Johnston, D., Hermans, J.M., and Yellowlees, D., Arch. Biochem. Biophys., 1995, vol. 324, pp. 35–40.

    Google Scholar 

  23. Zwilling, R., Neurath, H., Ericsson, L.H., and Enfield, D.L., FEBS Lett., 1975, vol. 60, pp. 247–249.

    Google Scholar 

  24. Zwilling, R. and Neurath, H., Methods Enzymol., 1981, vol. 80, pp. 633–664.

    Google Scholar 

  25. Tsu, C.A., Perona, J.J., Schellenberger, V., Turck, C.W., and Craik, C.S., J. Biol. Chem., 1994, vol. 269, pp. 19565–19572.

    Google Scholar 

  26. Miller, D.C., Zoologica, 1961, vol. 46, pp. 89–101.

    Google Scholar 

  27. Warner, G., The Biology of Crabs, London: Paul Elek, 1977.

    Google Scholar 

  28. Folk, J.E. and Cole, P.W., J. Biol. Chem., 1965, vol. 240, pp. 193–197.

    Google Scholar 

  29. Birkedal-Hansen, H., Moore, W., Bodden, M., Windsor, L., Birkedal-Hansen, B., DeCarlo, A., and Engler, J., Matrix Metalloproteinases: A Review, Crit. Rev. Oral Biol. Med., 1993, vol. 4, pp. 1197–1250.

    Google Scholar 

  30. Chen, Y.L., Lu, P.J., and Tsai, I.H., Comp. Biochem. Physiol., B: Comp. Biochem., 1991, vol. 100, pp. 763–768.

    Google Scholar 

  31. Welgus, H.G., Grant, G.A., Jeffry, J.J., and Eisen, A.Z., Biochemistry, 1982, vol. 21, pp. 5183–5189.

    Google Scholar 

  32. Grant, G.A. and Eisen, A.Z., Biochemistry, 1980, vol. 19, pp. 6089–6095.

    Google Scholar 

  33. Grant, G.A., Eisen, A.Z., and Bradshaw, R.A., Methods Enzymol., 1981, vol. 80, pp. 722–734.

    Google Scholar 

  34. Grant, G.A., Henderson, K.O., Eisen, A.Z., and Bradshaw, R.A., Biochemistry, 1980, vol. 19, pp. 4653–4659.

    Google Scholar 

  35. Sellos, D. and van Wormhoudt, A., FEBS Lett., 1992, vol. 309, pp. 219–224.

    Google Scholar 

  36. Tsu, C.A. and Craik, C.S., J. Biol. Chem., 1996, vol. 271, pp. 11 563–11 570.

    Google Scholar 

  37. Tsu, C.A., Perona, J.J., Fletterick, R.J., and Craik, C.S., Biochemistry, 1997, vol. 36, pp. 5393–5402.

    Google Scholar 

  38. Perona, J.J. and Craik, C.S., Protein Sci., 1995, vol. 4, pp. 337–360.

    Google Scholar 

  39. Perona, J.J., Tsu, C.A., Craik, C.S., and Fletterick, R.J., Biochemistry, 1997, vol. 36, pp. 5381–5392.

    Google Scholar 

  40. Alexander, M.E. and Dresden, M.H., Comp. Biochem. Physiol., B: Comp. Biochem., 1980, vol. 67, pp. 505–509.

    Google Scholar 

  41. Sangwan, V.S., Akpek, E.K., Voo, I., Zhao, T., Pinar, V., Yang, J., Christen, W., Baltasar, S., Wild, R., and Foster, C.S., Cornea, 1999, vol. 18, pp. 707–711.

    Google Scholar 

  42. Elyakova, L.A. and Kozlovskaya, E.P., USSR Inventor's Certificate no. 546648, Byull. Izobret., 1977.

  43. Artyukov, A.A. and Sakharov, I.Yu, RF Patent 4 806 987. 1995.

  44. Sakharov, I.Yu., Litvin, F.E., Artyukov, A.A., and Kofanova, N.I., USSR Inventor's Certificate no. 1526226, Byull. Izobret., 1989.

  45. Sakharov, I.Yu., Artyukov, A.A., and Berezin, V.I, RF Patent 1699350, 1991.

  46. Isaev, V.A., Rudenskaya, G.N., Kupenko, O.G., Stepanov, V.M., Popova, I.M., and Didenko, Yu.G., USSR Inventor's Certificate no. 2 008 353, Byull. Izobret., 1994.

  47. Sakharov, I.Yu., Litvin, F.E., and Mit'kevich, O.Z., Bioorg. Khim., 1994, vol. 20, pp. 120–125.

    Google Scholar 

  48. Klimova, O.A. and Chebotarev, V.Yu., Byull. Eksp. Biol. Med., 1999, vol. 128, pp. 308–313.

    Google Scholar 

  49. Rudenskaya, G.N., Isaev, V.A., Kalebina, T.S., Stepanov, V.M., Mal'tsev, K.V., Shvets, S.V., Luk'yanova, N.A., Kislitsin, Yu.A., and Miroshnikov, A.I., Bioorg. Khim., 1998, vol. 24, pp. 112–118.

    Google Scholar 

  50. Rudenskaya, G.N., Isaev, V.A., Shmoilov, A.M., Karabasova, M.A., Shvets, S.V., Miroshnikov, A.I., and Brusov, A.B., Appl. Biochem. Biotechnol., 2000, vol. 88, pp. 175–183.

    Google Scholar 

  51. Rudenskaya, G.N., Kupenko, O.G., Isaev, V.A., Stepanov, V.M., and Dunaevskii, Ya.E., Bioorg. Khim., 1995, vol. 21, pp. 249–255.

    Google Scholar 

  52. Rudenskaya, G.N., Shmoilov, A.M., Isaev, V.A., Ksenofontov, A.V., and Shvets, S.V., Biokhimiya (Moscow), 2000, vol. 65, pp. 23–30.

    Google Scholar 

  53. Kozlovskaya, E.P., Artyukhov, A.A., Kozlovskii, A.S., Vozhzhova, E.I., Kofanova, N.N., and Elyakov, G.B, RF Patent 95 122 189/14, 1995.

  54. Sakharov, I.Yu., Yagupov, N.A., Gurevich, V.A., Litvin, F.E., and Bobylev, G.F., USSR Inventor's Certificate no. 1 617 705.

  55. Sakharov, I.Yu., Glyantsev, S.P., Adamyan, A.A., Dobysh, S.V., Kochergina, L.D., Litvin, F.E., Artyukhov, A.A., and Kuznetsova, V.A, RF Patent 5002616, 1992.

  56. Isaev, V.A., Karabasova, M.A., Lyutova, L.V., Rudenskaya, G.N., Kupenko, O.G., and Stepanov, V.M., USSR Inventor's Certificate no. 2 057 534, 1996.

  57. Isaev, V.A., Rudenskaya, G.N., Brusov, A.B., Lyutova, L.V., Karabasova, M.A., Badnina, E.I., and Andreenko, G.V., RF Patent 98 101 769/14, 2000.

  58. Savvina, T.V., Glyantsev, S.P., and Zaets, T.L., Byul. Eksp. Biol. Med., 1996, vol. 121, pp. 716–720.

    Google Scholar 

  59. Sandakhchiev, L.S., Zinov'ev, V.V., Tsareva, A.A., et al., Vopr. Virusol., 1994, vol. 39, pp. 284–286.

    Google Scholar 

  60. Rudenskaya, G.N., Lyutova, L.V., Karabasova, M.A., Andreenko, G.V., Isaev, V.A., Brusov, A.V., Badnina, E.I., Reznikova, A.E., and Ageeva, L.V., Vestn. Mosk. Univ., 2000, vol. 41, pp. 414–416.

    Google Scholar 

  61. Sakharov, I.Yu., Glyantsev, S.P., Litvin, F.E., and Gordeev, V.F., Vopr. Med. Khim., 1994, vol. 40, no. 3, pp. 18–20.

    Google Scholar 

  62. Sandakhchiev, L.S., Stavskii, E.A., Zinov'ev, V.V., Nazarov, V.P., Renau, I.V., Satrikhina, T.N., Katkova, L.R., Krinitsin, L.A., Kolesnikova, L.V., Taranov, O.S., Omigov, V.V., Ovechkina, L.G., Markovich, N.A., Malygin, E.G., Danilenko, E.D., Voevoda, T.V., Fedoseeva, L.K., Sizova, L.Yu., and Masycheva, V.I., Vestn. Ross. Akad. Med. Nauk, 1998, vol. 4, pp. 50–55.

    Google Scholar 

  63. Paramonov, B.A., Klimova, O.A., and Chebotarev, V.Yu., Byull. Eksp. Biol. Med., 2000, vol. 129, pp. 556–559.

    Google Scholar 

  64. Adamyan, A.A., Glyantsev, S.P., Sakharov, I.Yu., and Savvina, T.V., Byull. Eksp. Biol. Med., 1992, vol. 114, pp. 660–663.

    Google Scholar 

  65. Sakharov, I.Yu. and Shekhonin, B.V., Byull. Eksp. Biol. Med., 1993, vol. 116, pp. 267–270.

    Google Scholar 

  66. Sakharov, I.Yu., Glyanzev, S.P., Litvin, F.E., and Savvina, T.V., Arch. Dermatol. Res., 1993, vol. 285, pp. 1–4.

    Google Scholar 

  67. Lyutova, L.V., Karabasova, M.A., Andreenko, G.V., Isaev, V.A., and Rudenskaya, G.N., Vopr. Med. Khim., 1998, vol. 44, pp. 292–295.

    Google Scholar 

  68. Ashmarin, I.P., Isaev, V.A., and Samsonov, M.A., Fiziologicheskie aspekty primeneniya eikonola i drugikh soderzhashchikh PNZhK-3 produktov pri zabolevaniyakh serdechno-sosudistoi sistemy, Metod. Rekomendatsii (Physiological Aspects of the Use of Eikonol and Other PNZhK-3 Products at the Illnesses of Cardiovascular System: Methodological Recommendations), Biological Department, Moscow State Univ., 1999.

  69. Dadashev, A.I., Yudanova, T.N., and Sakharov, I.Yu., Abstracts of Papers, 1st Int. Conf.: Contemporary Approaches to the Development of Efficient Dressing Means and Polymer Implants, November, 25–26, 1992, pp. 111–112.

  70. Madai, D.Yu., Shamolina, I.I., Zamyslova, T.I., Chufarovskaya, T.I., Balin, V.N., and Kosachev, I.D., Abstracts of Papers, 1st Int. Conf.: Contemporary Approaches to the Development of Efficient Dressing Means and Polymer Implants, November, 25–26, 1992, pp. 113–114.

  71. Kantemirova, B.F., Istranov, L.P., Shekhter, A.B., Aboyants, R.K., Istranova, E.V., Milovanova, Z.P., and Pankratova, S.V., Abstracts of Papers, 1st Inte. Conf.: Contemporary Approaches to the Development of Efficient Dressing Means and Polymer Implants, November, 25–26, 1992, pp. 117–118.

  72. Antonov, V.K., Vorotyntseva, T.I., and Zamolodchikova, T.S., Dokl. Ross. Akad. Nauk, 1991, vol. 324, pp. 1318–1322.

    Google Scholar 

  73. Zamolodchikova, T.S., Vorotyntseva, T.I., and Antonov, V.K., Eur. J. Biochem., 1995, vol. 227, pp. 866–872.

    Google Scholar 

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  1. Chemical Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899, Russia

    G. N. Rudenskaya

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Rudenskaya, G.N. Brachyurins, Serine Collagenolytic Enzymes from Crabs. Russian Journal of Bioorganic Chemistry 29, 101–111 (2003). https://doi.org/10.1023/A:1023248113184

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