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Antifungal activity of novel catecholamine ruthenium(III) complexes

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Abstract

New catecholamine ruthenium(III) complexes with potentially interesting biological activity are described. The complexes were prepared by reacting catecholamine with [RuCl(NH3)5]Cl2. The newly prepared species were formulated as [RuIII(NH3)4(catecholamine-R)]n+ where catecholamine-R = noradrenaline, dopamine and isoproterenol, and were characterized by elemental analysis, e.p.r., electronic absorption and f.t.-i.r. They were moderately stable in water at room temperature for at least 1 week. In vitro tests of antifungal activity showed the ruthenium–catecholamine complexes had strong inhibitory action against the pathogenic yeast Candida albicans, Candida glabrata and Candida tropicalis. Free catecholamine does not show any antifungal activity.

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Authors and Affiliations

  1. Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto – USP, Av. dos Bandeirantes, 3900, 14040-901, Ribeirão Preto, São Paulo, Brazil

    Renata Galvão de Lima

  2. Department of Chemistry, York University, 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3

    A.B.P. Lever

  3. Faculdade de Ciências Farmacêuticas de Ribeirão Preto – USP, Av. do Café s/n, 14040-903, Ribeirão Preto, São Paulo, Brazil

    Izabel Y. Ito & Roberto Santana da Silva

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  1. Renata Galvão de Lima
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  2. A.B.P. Lever
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  3. Izabel Y. Ito
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  4. Roberto Santana da Silva
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de Lima, R.G., Lever, A., Ito, I.Y. et al. Antifungal activity of novel catecholamine ruthenium(III) complexes. Transition Metal Chemistry 28, 272–275 (2003). https://doi.org/10.1023/A:1022967403627

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