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REFERENCES
K. Ichikawa, I. Ohata, M. Mitomi, S. Kawamura, H. Maeno, and H. Kawata. Rectal absorption of insulin suppositories in rabbits. J. Pharm. Pharmacol. 32:314–318 (1980).
K. A. Walters, P. H. Dugard, and A. T. Florence. Non-ionic surfactants and gastric mucosal transport of paraquat. J. Pharm. Pharmacol. 33:207–213 (1981).
S. Guarini and W. Ferrari. Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastrointestinal tract. Arch. Int. Pharmacodyn. 271:4–10 (1984).
M. Yonezawa. Basic studies of the intestinal absorption. I. Changes in the rabbit intestinal mucosa after exposure to various surfactants. Nihon Univ. J. Med. 19:125–141 (1977).
A. J. Bryan, R. Kaur, G. Robinson, N. W. Thomas, and C. G. Wilson. Histological and physiological studies on the intestine of the rat exposed to solutions of Myrj 52 and PEG 2000. Int. J. Pharm. 7:145–156 (1980).
K. J. Macek and S. F. Krzeminski. Susceptibility of bluegill sunfish (Lepomis macrochirus) to non-ionic surfactants. Bull. Environ. Contam. Toxicol. 13:377–384 (1975).
H. F. Smyth and J. C. Calandra. Toxicologic studies of alkylphenol polyoxyethylene surfactants. Toxicol. Appl. Pharmacol. 14:315–334 (1969).
E. S. Swenson, W. B. Milisen, and W. Curatolo. Intestinal permeability enhancement: Efficacy, acute local toxicity, and reversibility. Pharm. Res. 11:1132–1142 (1994).
M. V. Teem and S. F. Phillips. Perfusion of the hamster jejunum with conjugated and unconjugated bile acids: inhibition of water absorption and effects on morphology. Gastroenterology 62:261–267 (1972).
G. W. Gullikson, W. S. Cline, V. Lorenzsonn, L. Benz, W. A. Olsen, and P. Bass. Effects of anionic surfactants on hamster small intestinal membrane structure and function: relationship to surface activity. Gastroenterology, 73:501–511 (1977).
H. S. Mekhjian, S. F. Phillips, and A. F. Hofmann. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J. Clin. Invest. 50:1569–1577 (1971).
E. J. van Hoogdalem, A. G. deBoer, and D. D. Breimer. Intestinal drug absorption enhancement: an overview. Pharmac. Ther. 44:407–443 (1989).
E. S. Swenson and W. Curatolo. Intestinal permeability enhancement for proteins, peptides, and other polar drugs: mechanisms and potential toxicity. Adv. Drug Del. Rev. 8:39–92 (1992).
W. C. Griffin. Classification of surface active agents by “HLB”. J. Soc. Cosmet. Chem. 1:311–326 (1947).
W. C. Griffin. Calculation of HLB values of non-ionic surfactants. J. Soc. Cosmet. Chem. 5:249–256 (1954).
A. T. Florence. Surfactant interactions with biomembranes and drug absorption. Pure Appl. Chem. 53:2057–2068 (1981).
K. Nishida, C. Tonegawa, T. Kakutani, M. Hashida, and H. Sezaki. Statistical moment analysis of hepatobiliary transport of phenol red in the perfused rat liver. Pharm. Res. 6:140–146 (1989).
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Swenson, E.S., Milisen, W.B. & Curatolo, W. Intestinal Permeability Enhancement: Structure-Activity and Structure-Toxicity Relationships for Nonylphenoxypolyoxyethylene Surfactant Permeability Enhancers. Pharm Res 11, 1501–1504 (1994). https://doi.org/10.1023/A:1018920728800
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DOI: https://doi.org/10.1023/A:1018920728800