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Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal Content

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REFERENCES

  1. J. P. Brown, G. V. McGarraugh, T. M. Parkinson, R. E. Wingard, Jr., and A. B. Onderdonk. A polymer drug for treatment of inflammatory bowel disease. J. Med. Chem. 26:1300–1307 (1983).

    Google Scholar 

  2. C. Larsen and B. H. Jensen. Stability of ketoprofen-dextran ester prodrugs in homogenates of various segments of the pig tract. Acta Pharm. Nord. 3:41–44 (1991).

    Google Scholar 

  3. T. N. Tozer, J. Rigod, A. D. McLeod, R. Gungon, M. K. Hoag, and D. R. Friend. Colon-specific delivery of dexamethasone from a glucoside prodrug in the guinea pig. Pharm. Res. 8:445–454 (1991).

    Google Scholar 

  4. A. Wastenson. Properties of fractionated chondroitin sulphate from ox nasal septa. Biochem. J. 122:477–485 (1971).

    Google Scholar 

  5. O. M. S. Toledo and C. P. Dietrich. Tissue specific distribution of sulfated mucoplysaccharides in mammals. Biochim. Biophys. Acta 498:114–122 (1977).

    Google Scholar 

  6. A. A. Salyers. Energy sources of major intestinal fermentative anaerobes. Am. J. Clin. Nutr. 32:158–163 (1979).

    Google Scholar 

  7. A. A. Salyers and M. O'Brien. Cellular location of enzymes involved in chondroitin sulfate breakdown by Bacteroide thetaiotaomicron. J. Bacteriol. 143:772–780 (1980).

    Google Scholar 

  8. J. C. Sheehan. A new method of forming peptide bonds. J. Am. Chem. Soc. 77:1067–1068 (1955).

    Google Scholar 

  9. I. Lutsky, F. Aizer, and N. Mor. The Sabra rat: Definition of a laboratory animal. Isr. J. Med. Sci. 20:603–612 (1984).

    Google Scholar 

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Rubinstein, A., Nakar, D. & Sintov, A. Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal Content. Pharm Res 9, 276–278 (1992). https://doi.org/10.1023/A:1018910128452

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  • DOI: https://doi.org/10.1023/A:1018910128452

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