Abstract
The study aimed at applying closed segmentalintestinal perfusion with a multichannel tube(Loc-I-Gut) for studies of regional small bowelpermeability to different-sized polyethylene glycols andto compare jejunal absorption with absorption after oralload in healthy subjects. Intestinal perfusion wasperformed in 10 healthy volunteers and recovery of14C-labeled polyethylene glycol 4000 was usedto detect leakage. Absorption of polyethylene glycols546-942 was measured as urinary recovery after perfusionand oral load, and as disappearance from the lumenduring steady-state perfusion. Steady-state conditions were obtained during the second hour ofperfusion. Absorption of polyethylene glycols duringperfusion was size-selective for molecular weights546-766, but not for 810-942. After oral load,absorption was size-selective throughout 546-942.Segmental perfusion with Loc-I-Gut may be used to studyregional jejunal permeability. Our data support thehypothesis of a dual pore system for absorption ofhydrophilic molecules in the human jejunum.
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Soderholm, J.D., Olaison, G., Kald, A. et al. Absorption Profiles for Polyethylene Glycols After Regional Jejunal Perfusion and Oral Load in Healthy Humans. Dig Dis Sci 42, 853–857 (1997). https://doi.org/10.1023/A:1018836803254
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DOI: https://doi.org/10.1023/A:1018836803254