Abstract
This study demonstrates that the molecular weight of polyalkylcyanoacrylate nanoparticles can be modified by the composition of the polymerization medium, the nature of the monomers and the drug to be linked to the carrier. The influence of a surfactive agent is particularly important because polymers of very high molecular weight have been obtained. Likewise, polyalkylcyanoacrylate molecular weight distribution has been greatly modified after binding doxorubicin to nanoparticles. These long polymers could induce important changes in carrier degradation, in bound drug bioavailability and in polymer excretion rate. Some additional findings have been added concerning the state of polyalkylcyanoacrylate polymer during the degradation process.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Couvreur, P., Roland, M., Speiser, P. (1982) US Patent 4, 320, 332.
Couvreur, P., Kante, B., Roland, M., Guiot, P., Baudhuin, P., Speiser, P. (1979) J. Pharm. Pharmacol. 31, 331–332.
Brasseur, F., Couvreur, P., Kante, B., Deckers-Passau, L., Roland, M., Deckers, C., Speiser, P. (1980) Europ. J. Cancer 16, 1441–1445.
Couvreur, P., Kante, B., Grislain, L., Roland, M., Speiser, P. (1982) J. Pharm. Sci. 71, 790–792.
Grislain, L., Couvreur, P., Lenaerts, V., Roland, M., Deprez-Decampeneere, D., Speiser, P. (1983) Int. J. Pharm. 15, 335–345.
Vezin, W. R., Florence, A. T. (1980) J. Biomed. Mat. Res. 14, 93–106.
Lenaerts, V., Couvreur, P., Christiaens-Leyh, D., Joiris, E., Roland, M., Rollman, B., Speiser, P. (1984) Biomaterials 5, 65–68.
El-Egakey, M. A., Bentele, V., Kreuter, J. (1983) Int. J. Pharm. 3, 349–352.
Sun, S. F., Wong, F. (1981) J. Chromatography 208, 253–259.
Lenaerts, V., Nagelkerke, J. F., Van Berkel, T. J. C., Couvreur, P., Grislain, L., Roland, M., Speiser, P. (1984) J. Pharm. Sci. 73, 980–982.
Briseid, G., Briseid, K. (1980) Acta Pharmacol. Toxicol. 47, 119–126.
Leonard, F., Kulkarni, R. K., Brandes, G., Nelson, J., Cameron, J. J. (1966) J. Appl. Polym. Sci. 10, 259–272.
Kreuter, J. (1978) Pharm. Acta Helv. 53, 33–39.
Oppenheim, R. C. (1981) Int. J. Pharm. 8, 217–234.
Kramer, P. A. (1974) J. Pharm. Sci. 63, 1646–1647.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vansnick, L., Couvreur, P., Christiaens-Leyh, D. et al. Molecular Weights of Free and Drug-Loaded Nanoparticles. Pharm Res 2, 36–41 (1985). https://doi.org/10.1023/A:1016366022712
Issue Date:
DOI: https://doi.org/10.1023/A:1016366022712