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Demonstration of Sucralfate-mediated Preservation of Growth Factor Bioactivity in the Presence of Low pH with a Human Gastric Epithelial Cell Line (AGS)

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REFERENCES

  1. P. ten Dijke and K. K. Iwata. Growth factors for wound-healing. Biotechnology 7:793–798 (1989).

    Google Scholar 

  2. P. K. Tsai, D. B. Volkin, J. M. Dabora, K. C. Thompson, M. W. Bruner, J. O. Gress, B. Matuszewska, M. Keogan, J. V. Bondi, and C. R. Middaugh. Formulation design of acidic fibroblast growth factor. Pharm. Res. 10:649–659 (1993).

    Google Scholar 

  3. D. B. Volkin, A. M. Verticelli, K. E. Marfia, C. J. Burke, H. Mach, and C. R. Middaugh. Sucralfate and soluble sucrose octa-sulfate bind and stabilize acidic fibroblast growth factor. Biochim. Biophys. Acta 1203:18–26 (1993).

    Google Scholar 

  4. K. Fukunaga, S. Hijikata, K. Ishimura, R. Sonoda, T. Irie, and K. Uekama. Aluminum β-cyclodextrin sulphate as a stabilizer and sustained-release carrier for basic fibroblast growth factor. J. Pharm. Pharmacol. 46:168–171 (1994).

    Google Scholar 

  5. D. Gospodarowicz and J. Cheng. Heparin protects basic and acidic FGF from inactivation. J. Cell. Physiol. 128:475–484 (1986).

    Google Scholar 

  6. J. Folkman, S. Szabo, M. Stovroff, P. Mcneil, W. Li, and Y. Shing. Duodenal ulcer: discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann. Surg. 214:414–427 (1991).

    Google Scholar 

  7. S. J. Prestrelski, G. M. Fox, and T. Arakawa. Binding of heparin to basic fibroblast growth factor induces a conformational change. Arch. Biochem. Biophys. Acta 293:314–319 (1992).

    Google Scholar 

  8. S. Faham, R. E. Hileman, J. R. Fromm, R. J. Linhardt, and D. C. Rees. Heparin structure and interactions with basic fibroblast growth factor. Science 271:1116–1120 (1996).

    Google Scholar 

  9. S. J. Konturek, T. Brzozowski, J. Majka, A. Szlachcic, W. Bielanski, J. Stachura, and W. Otto. Fibroblast growth factor in gastroprotection and ulcer healing:interaction with sucralfate. Gut 34:881–887 (1993).

    Google Scholar 

  10. H. Kuwayama, T. Naito, and Y. Kojima. Proliferative response of rabbit and rat gastric epithelial cells to human epidermal growth factor. Digestion 55:108–114 (1994).

    Google Scholar 

  11. H. Paimela, P. J. Goddard, K. Carter, R. Khakee, P. L. McNeil, S. Ito, and W. Silen. Restitution of frog gastric mucosa in vitro: Effect of basic fibroblast growth factor. Gastroenterology 104:1337–1345 (1993).

    Google Scholar 

  12. E. Nexo and S. S. Poulsen. Does epidermal growth factor play a role in the action of sucralfate? Scand. J. Gastroent. 22 (Suppl 127):45–49 (1987).

    Google Scholar 

  13. S. C. Barranco, C. M. Townsend, C. Casartelli, Jr., B. G. Macik, N. L. Burger, W. R. Boerwinkle, and W. K. Gourley. Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach. Cancer Res. 43:1703–1709 (1983).

    Google Scholar 

  14. H. Zheng, P. K. Shah, and K. L. Audus. Evaluation of antiulcer agents with a human adenocarcinoma cell line (AGS). Int. J. Pharm., 129:103–112 (1996).

    Google Scholar 

  15. H. Zheng, P. K. Shah, and K. L. Audus. Primary culture of rat gastric epithelial cells as an in vitro model to evaluate antiulcer agents. Pharm. Res. 11:77–82 (1994).

    Google Scholar 

  16. M. Piontek, K. J. Hengels, R. Porschen, and G. Strohmeyer. Antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of gastric cancer cells. Anticancer Res. 13:2119–2123 (1994).

    Google Scholar 

  17. A. U. Dignass, S. Tsunekawa, and D. K. Podolsky. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 106:1254–1262 (1994).

    Google Scholar 

  18. R. Nagashima. Development and characteristics of sucralfate. J. Clin. Gastroenterol. 3(suppl. 2):103–110 (1981).

    Google Scholar 

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Author notes

  1. Kenneth L. Audus

    Present address: Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, 66045

Authors and Affiliations

  1. Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66045

    Huaibao Sheng & Kenneth L. Audus

  2. Hoechst Marion Roussell, Kansas City, Missouri, 64134

    Praful K. Shah

Authors
  1. Huaibao Sheng
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  2. Praful K. Shah
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  3. Kenneth L. Audus
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Sheng, H., Shah, P.K. & Audus, K.L. Demonstration of Sucralfate-mediated Preservation of Growth Factor Bioactivity in the Presence of Low pH with a Human Gastric Epithelial Cell Line (AGS). Pharm Res 13, 1122–1126 (1996). https://doi.org/10.1023/A:1016035513974

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  • DOI: https://doi.org/10.1023/A:1016035513974

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