Abstract
To evaluate the potentiality of the blue-green algae Spirulina platensis as a matrix for the production of Se-containing pharmaceuticals, the background levels of 31 major, minor and trace elements (Na, Mg, Al, Cl, K, Ca, Sc, V, Cr, Mn, Fe, Co, Ni using (n,p) reaction), As, Br, Zn, Rb, Mo, Ag, Sb, I, Ba, Sm, Tb, Tm, Hf, Ta, W, Au, Hg, Th were determined in Spirulina platensis biomass by means of epithermal neutron activation analysis. The possibility of the purpose-oriented incorporation of Se into Spirulina platensis biomass was demonstrated. The polynomial dependence of the Se accumulation on nutritional medium loading was revealed. The analytical technique used allows to control the amount of toxic elements in algae Spirulina platensis. Based on this study, a conclusion of the possibility to use Spirulina platensisas a matrix for the production of Se-containing pharmaceutical was drawn.
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References
D. FOX, Health Benefits of Spirulina, in: Spirulina, Algae of Life.; Bulletin No. 12. April 1993, Publ. by Institute of Oceanography, Monaco.
H. FOSTER, Health, Disease and the Environment, Belhaven Press, London, 1992.
G. F. COMBS JR., Med. Klin., 94, Suppl. 3 (1999) 18.
M. NAVARRO-ALARCON, DE LA H. L. SERRANA, V. PEREZ-VALERO, C. LOPEZ-MARTINEZ, Sci. Total Environ., 212 (1998) 195.
K. SCHUMACHER, Med. Klin., 94, Suppl 3 (1999) 45.
R. EBERT-DUMING, J. SEUFERT, D. SCHNEIDER, J. KOHREL, N. SCHUTZE, F. JACOB, Med. Klin., 94, Suppl 3 (1999) 29.
D. H. HOLBEN, A. M. SMITH, J. An. Diet. Assoc., 99 (1999) 836.
M. V. FRONTASYEVA, E. STEINNES, Proc. Intern. Symp. on Harmonization of Health Related Environmental Mesurements Using Nuclear and Isotopic Techniques, Hyderabad, India, 4-7 November, 1996, IAEA 1997, p. 301.
L. M. MOSULISHVILI, V. S. NADAREISHVILI, N. E. KHARABADZE, A. I. BELOKOBILSKY, Patent USSR N779765, Bull., 42 (1980).
L. M. MOSULISHVILI, N. E. KHARABADZE, A. I. BELOKOBYLSKY, A. Sh. GUDUSHAURI, Proc. Georg. AS, Biol.Ser., 98 (1980) No. 3, 685.
V. M. NAZAROV, S. S. PAVLOV, E. HERRERA, M. V. FRONTASYEVA, J. Radioanal. Nucl. Chem., 167 (1993) 11.
T. M. OSTROVNAYA, L. S. NEFEDYEVA, V. M. NAZAROV, S. B. BORZAKOV, L. P. STRELKOVA, Proc. Analysis in Environment Protection, D-14-93-325, Dubna, 1993, p. 319.
L. M. MOSULISHVILI, N. E. KUCHAVA, N. I. SHONIA, Proc. Georg. AS, Biol. Ser., 107 (1982) No. 2, 501.
L. M. MOSULISHVILI, V. YU. DUNDUA, N. E. KHARABADZE, E. YU. EFREMOVA, N. V. CHIKHLADZE, J. Radioanal. Nucl. Chem., 83 (1984) 13.
A. BELOKOBILSKY, M. GELASHVILI, L. MOSULISHVILI, A. RCHEULISHVILI, A. KHIZANISHVILI, Proc. Georg. AS, Biol. Ser., 22 (1996) Nos 1-6, 104.
A. BELOKOBILSKY, N. TSIBACHASHVILI, A. RCHEULISHVILI, L. MOSULISHVILI, Bul. Georg. AS., 159 (1999) No. 1, 140.
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Mosulishvili, L.M., Kirkesali, Y.I., Belokobylsky, A.I. et al. Epithermal neutron activation analysis of blue-green algae Spirulina platensis as a matrix for selenium-containing pharmaceuticals. Journal of Radioanalytical and Nuclear Chemistry 252, 15–20 (2002). https://doi.org/10.1023/A:1015219300665
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DOI: https://doi.org/10.1023/A:1015219300665