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Forecasting the Oral Absorption Behavior of Poorly Soluble Weak Bases Using Solubility and Dissolution Studies in Biorelevant Media

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REFERENCES

  1. A. A. Noyes and W. R. Whitney. Ñber die Auflösungsgeschwindigkeit von festen Stoffen in ihren eigenen Lösungen. Zeitschrift f. Physikal. Chemie 23:689–692 (1897).

    Google Scholar 

  2. W. Nernst and E. Brunner. Theorie der Reaktionsgeschwindigkeit in heterogenen Systemen. Zeitschrift f. Physik. Chemie 47:52–110 (1904).

    Google Scholar 

  3. V. G. Levich. Physicochemical Hydrodynamics, Engelwood Cliffs, Prentice Hall, New Jersey, 1962.

    Google Scholar 

  4. J. B. Dressman, G. L. Amidon, C. Reppas, and V. P. Shah. Dissolution testing as a prognostic tool for oral drug absorption-immediate release dosage forms. Pharm. Res. 15:11–22 (1998).

    Google Scholar 

  5. T. Bates, M. Gibaldi, and J. Kanig. Solubilizing properties of bile salt solutions I. J. Pharm. Sci. 55:191–199 (1966).

    Google Scholar 

  6. E. Nicolaides, E. Galia, C. Efthymiopoulos, J. B. Dressman, and C. Reppas. Forecasting the in vivo performance of four low solubility drugs from their in vitro dissolution data. Pharm. Res. 16: 1876–1882 (1999).

    Google Scholar 

  7. E. Galia, E. Nicolaides, D. Hörter, R. Löbenberg, C. Reppas, and J. B. Dressman. Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs. Pharm. Res. 15:698–705 (1998).

    Google Scholar 

  8. U. Klotz, H. Kroemer, and M. Schulz. Pantoprazole, der dritte Protonenpumpinhibitor. Pharm. Zeitung 32:24–32 (1995).

    Google Scholar 

  9. J. B. Dressman, R. R. Berardi, L. C. Dermentzoglou, T. L. Russell, S. P. Schmaltz, J. L. Barnett, and K. M. Jarvenpaa. Upper gastrointestinal (GI) pH in young, healthy men and women. Pharm. Res. 7:756–761 (1990).

    Google Scholar 

  10. L. Ovesen, F. Bentsen, U. Tage-Jentsen, N. T. Pedersen, B. R. Gram, and S. J. Rune. Intraluminal pH in the stomach, duodenum and proximal jejunum in normal subjects and patients with exocrine pancreatic insufficiency. Gastroenterology 90:958 (1986).

    Google Scholar 

  11. T. L. Russell, R. R. Berardi, J. L. Barnett, T. L. Osullivan, J. G. Wagner, and J. B. Dressman. pH-Related changes in the absorption of dipyridamole in the elderly. Pharm. Res. 11:136–143 (1994).

    Google Scholar 

  12. A. Melander. Influence of food on the bioavailability of drugs. Clin. Pharm. 3:337–351 (1978).

    Google Scholar 

  13. T. J. Mellinger and J.G. Bohorfoush. Blood levels of dipyridamole (Persantin®) in humans. Arch. Int. de Pharmacodyn. 163: 471–480 (1966).

    Google Scholar 

  14. S. D. Mithani. Dissolution and precipitation of dipyridamole: effect of pH and bile salt concentration, Doctoral Thesis, The University of Michigan, Ann Abor, Michigan, 1998.

    Google Scholar 

  15. B. Terhaag, F. Donath, G. Le Petit, and K. Feller. The absolute and relative bioavailability of dipyridamole from different preparations and the in vitro-in vivo comparison. Int. J. Clin. Pharmacol. Ther. Toxicol. 24:298–302 (1986).

    Google Scholar 

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Correspondence to Jennifer B. Dressman.

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Kostewicz, E.S., Brauns, U., Becker, R. et al. Forecasting the Oral Absorption Behavior of Poorly Soluble Weak Bases Using Solubility and Dissolution Studies in Biorelevant Media. Pharm Res 19, 345–349 (2002). https://doi.org/10.1023/A:1014407421366

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