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Encapsulation of deoxyribonucleic acid molecules in silica and hybrid organic-silica gels

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Abstract

The encapsulation of small DNA molecules was attempted in pure silica and in hybrid polyvinyl alcohol-silica gels. The materials which were obtained were examined by nitrogen adsorption, and by 29Si and 31P NMR spectroscopy. The extraction of the DNA molecules from the gels was examined in a buffer aqueous solution as well as in an acidic medium. The results suggested that the DNA molecules remained trapped inside the gels due to a permanent bonding to the gel network.

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References

  1. M. T. REETZ, A ZONTA and J. SIMPELKAMP, Biotechnology andBioengineering 49 (1996) 527.

    Google Scholar 

  2. D. J. BLYTH, J. W. AYLOTT, D. J. RICHARDSON and D.A. RUSSELL, Analyst 120 (1995) 2725.

    Google Scholar 

  3. S. LOWELL and J. E. SHIELDS, “PowderSurface Area and Porosity”, 3rd edition (Chapman and Hall Ltd, London, 1991).

    Google Scholar 

  4. R. H. GLASER, G.L. WILKES and E. BRONNIMANN, J. Non-Cryst. Solids 113 (1989) 73.

    Google Scholar 

  5. J. C. TEBBY, in“Phosprus-31 NMR Spectroscopy in Sterochemical Analysis” Methods in Sterochemical Analysis 8, edited by J. G. VERKADE and L. D. QUIN, (VCH Publishers, Inc., DeerÆeld, Florida, USA, 1987) pp. 1–60.

    Google Scholar 

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Authors and Affiliations

  1. Institut de Recherches sur la Catalyse, Université Claude Bernard-Lyon I, 2 avenue Albert Einstein, 69626, Villeurbanne Cedex, France

    A. Pierre

  2. Laboratoire d'Immunologie Moléculaire, Zone Nord Bât. 1b, Université de Bordeaux II, 146 rue Léo Saignet, 33076, Bordeaux Cedex, Francen

    J. Bonnet & A. Vekris

  3. GIS-vivo, center Condorcet, 162 Av. du Dr. Albert Schweitzer, 33608, Pessac, France

    J. Bonnet, A. Vekris & J. Portier

  4. Institut de Chimie de la Matiè Condensée de Bordeaux, Château Brivazac, Université de Bordeaux I, Av. du Dr. Albert Schweitzer, 33600, Pessac, France

    J. Portier

Authors
  1. A. Pierre
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  2. J. Bonnet
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  3. A. Vekris
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  4. J. Portier
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Pierre, A., Bonnet, J., Vekris, A. et al. Encapsulation of deoxyribonucleic acid molecules in silica and hybrid organic-silica gels. Journal of Materials Science: Materials in Medicine 12, 51–55 (2001). https://doi.org/10.1023/A:1013857102461

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  • DOI: https://doi.org/10.1023/A:1013857102461

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