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The Chlorhexidine: beta;-Cyclodextrin Inclusion Compound: Preparation, Characterization and Microbiological Evaluation

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Abstract

The 1 : 2 chlorhexidine : β-cyclodextrin(Cx : βCD) complex was prepared and characterised using X-ray crystallography, infrared spectroscopy, thermal analysis and nuclearmagnetic resonance. The minimum inhibitory concentration (MIC50) of the chlorhexidine : β-cyclodextrin inclusion compoundagainst Streptococcus mutans, Eubacterium Lentum, Fusobacterium nucleatum, Bacteroides fragilis andActinomices actinomycetemcomitans was determined. TheCx : βCD inclusion compound inhibited the bacterial growth at a low concentration.

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Authors and Affiliations

  1. Dpto. de Odontologia Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, CEP, 31270-901, Belo Horizonte, Brazil

    Maria Esperanza Cortés

  2. Dpto. de Química, ICEX, UFMG, Brazil

    Rubén Dario Sinisterra

  3. Dpto. de Microbiologia, ICB, Brazil

    Mario Julio Avila-Campos

  4. Faculdade de Odontologia, Universidade de São Paulo, Brazil

    Nicolau Tortamano & Rodney Garcia Rocha

Authors
  1. Maria Esperanza Cortés
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  2. Rubén Dario Sinisterra
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  3. Mario Julio Avila-Campos
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  4. Nicolau Tortamano
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  5. Rodney Garcia Rocha
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Cortés, M.E., Sinisterra, R.D., Avila-Campos, M.J. et al. The Chlorhexidine: beta;-Cyclodextrin Inclusion Compound: Preparation, Characterization and Microbiological Evaluation. Journal of Inclusion Phenomena 40, 297–302 (2001). https://doi.org/10.1023/A:1012788432106

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