Abstract
A bidentate and a quadridentate Schiff base having NS and NNSS donor sequences were prepared by condensing S-benzyldithiocarbazate (NH2NHCSSCH2Ph) with 2,3-butanedione (1:1 and 1:2 mole ratio). NiII and CuII complexes of these ligands were studied and characterised by elemental analyses and various physico-chemical techniques. The nickel complexes, [Ni(NS)2] and [Ni(SNNS)], were diamagnetic with square-planar and five-coordinate structures, respectively. The copper complex was, however, pentacoordinated. The ligands and the complexes were screened for anticancer activity against T-lymphoblastic leukemic cells (CEM-SS) and colon cancer cells (HT-29). The NS Schiff base was strongly active against leukemic cells with a CD50 value of 2.05 μg cm−3. The nickel and copper complexes were found to be stronger antioxidants than Vitamin E.
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Tarafder, M.T.H., Saravanan, N., Crouse, K.A. et al. Coordination chemistry and biological activity of nickel(II) and copper(II) ion complexes with nitrogen–sulphur donor ligands derived from S-benzyldithiocarbazate (SBDTC). Transition Metal Chemistry 26, 613–618 (2001). https://doi.org/10.1023/A:1012047001167
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DOI: https://doi.org/10.1023/A:1012047001167