Skip to main content
SpringerLink
Log in

An Investigation into the Surface Deposition of Progesterone on Poly (d,l-) Lactic Acid Microspheres Using Micro-Thermal Analysis

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. T. L. Whateley. Biodegradable microspheres for controlled drug delivery. In D. R. Karsa and R. A. Stephenson (eds.), Encapsulation and Controlled Release, Royal Society of Chemistry, 1993 pp. 54-65.

  2. Y. Ogawa. Injectable microcapsules prepared with biodegradable poly(α-hydroxy) acids for prolonged release of drugs. J. Biomater. Sci. Polymer Edn. 8:391-409 (1997).

    Google Scholar 

  3. B. R. Conway, J. E. Eyles, and H. O. Alpar. A comparative study on the immune responses to antigens in PLA and PHB microspheres. J. Control. Release 49:1-9 (1997).

    Google Scholar 

  4. M. van de Weert, R. van't Hof, J. van der Weerd, R. M. A. Heeren, G. Posthuma, W. E. Hennink and D. J. A. Crommelin, Lysozome distribution and conformation in a biodegradeable polymer matrix as determined by FTIR techniques. J. Control. Release 68:31-40 (2000).

    Google Scholar 

  5. J. P. Benoît, F. Courteille, and C. Thies. A physiochemical study of the morphology of progesterone-loaded poly(D,L-lactide) microspheres. Int. J. Pharm. 29:95-102 (1986).

    Google Scholar 

  6. S. Benita, J. P. Benoît, F. Puisieux, and C. Thies. Characterisation of drug-loaded poly(d,l-lactide) microspheres. J. Pharm. Sci. 73:1721-1724 (1984).

    Google Scholar 

  7. V. L. Hill, N. Passerini, D. Q. M. Craig, M. Vickers, J. Anwar, and L. C. Feely. Investigation of progesterone loaded poly(d,l-lactide) microspheres using TMDSC, SEM and PXRD. J. Therm. Anal. 54:673-685 (1998).

    Google Scholar 

  8. A. Hammiche, M. Reading, H. M. Pollock, M. Song, and D. Hourston. Localised thermal analysis using a miniaturised resistive probe. Rev. Sci. Inst. 67:4268-4274 (1996).

    Google Scholar 

  9. M. Reading, D. M. Price, H. M. Pollock, A. Hammiche, and A. Murray. Recent progress in microthermal analysis. Am. Lab. 31:13-16 (1999).

    Google Scholar 

  10. D. M. Price, M. Reading, A. Hammiche, and H. M. Pollock. Micro-thermal analysis: Scanning thermal microscopy and localised thermal analysis. Int. J. Pharm. 192:85-96 (1999).

    Google Scholar 

  11. P. G. Royall, D. Q. M. Craig, D. M. Price, M. Reading, and T. J. Lever An investigation into the use of micro-thermal analysis for the solid state characterisation of an HPMC tablet formulation. Int. J. Pharm. 192:97-103 (1999).

    Google Scholar 

  12. P. G. Royall and D. Q. M. Craig. Micro-thermal analysis of a coated tablet: A simple method for the enhancment of the DC thermal image. J. Pharm. Pharmacol. 51S:89 (1999).

    Google Scholar 

  13. M. J. Pikal and S. Shah. The collapse temperature in freeze drying: Dependence on measurement methodology and rate of water removal from the glassy phase. Int. J. Pharm. 62:165-186 (1990).

    Google Scholar 

  14. J. M. Hutchinson. Characterising the glass transition and relaxation kinetics by conventional and temperature-modulated differential scanning calorimetry. Thermochim. Acta 324:165-174 (1998).

    Google Scholar 

  15. J. Kerç and S. Srçiç. Thermal analysis of glassy pharmaceuticals. Thermochim. Acta 248:81-95 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacy, School of Health and Life Sciences, King's College London, Franklin-Wilkins Building, 150 Stanford Street, London SE1 8WA; b. Imperial College of Science & Technology, Exhibition Road, London, SW7 2AZ, UK, University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK 1. IPTME, Loughborough University, Loughborough LE11 3TU, UK. a

    Paul G. Royall

  2. University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK 1. IPTME, Loughborough University, Loughborough LE11 3TU, UK

    Vivienne L. Hill, Duncan M. Price & Mike Reading

  3. University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK 1. IPTME, Loughborough University, Loughborough LE11 3TU, UK. (e-mail

    Duncan Q. M. Craig

Authors
  1. Paul G. Royall
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vivienne L. Hill
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Duncan Q. M. Craig
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Duncan M. Price
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mike Reading
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Royall, P.G., Hill, V.L., Craig, D.Q.M. et al. An Investigation into the Surface Deposition of Progesterone on Poly (d,l-) Lactic Acid Microspheres Using Micro-Thermal Analysis. Pharm Res 18, 294–298 (2001). https://doi.org/10.1023/A:1011094611784

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1011094611784

Search

Navigation