Skip to main content
SpringerLink
Log in

Controlled Release of Insulin from Injectable Biodegradable Triblock Copolymer

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  1. S. Cohen, T. Yoshioka, M. Lucarelli, L. H. Hwang, and R. Langer. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8:713-720 (1991).

    Google Scholar 

  2. E. A. Pec, Z. G. Wout, and T. P. Johnston. Biological Activity of urease formulated in poloxamer 407 after intraperitoneal injection in the rat. J. Pharm. Sci. 81:626-630 (1992).

    Google Scholar 

  3. L. Youxin and T. Kissel. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid) or poly(L-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J. Control. Release 27:247-257 (1993).

    Google Scholar 

  4. M. Malstom and B. Lindman. Self-assembly in aqueous block copolymer solutions. Macromolecules 25:5440-5445 (1992).

    Google Scholar 

  5. B. Jeong, Y. H. Bae, D. S. Lee, and S. W. Kim. Biodegradable block copolymers as injectable drug-delivery systems. Nature 388:860-862 (1997).

    Google Scholar 

  6. B. Jeong, D. S. Lee, J. Shon, Y. H. Bae, and S. W. Kim. Thermoreversible gelation of poly(ethylene oxide) biodegradable polyester block copolymers. J. Polym. Sci.: Part A: Polym. Chem. 37:751-780 (1999).

    Google Scholar 

  7. R. Rathi and G. Zentner. Biodegradable, low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties. U.S. Patent 6,004,573.

  8. B. Jeong, Y. H. Bae, and S. W. Kim. Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J. Control. Release 63:155-163 (2000).

    Google Scholar 

  9. B. Jeong, Y. H. Bae, and S. W. Kim. In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J. Biomed. Mater. Res. 50:171-177 (2000).

    Google Scholar 

  10. R. Baker. In Controlled Release of Bioactive Materials, Academic Press, New York, 1980.

    Google Scholar 

  11. M. Baudys and S. W. Kim. Preface. Adv. Drug Delivery Rev. 35:141-142 (1999).

    Google Scholar 

  12. M. Hinchcliffe and L. Illum. Intranasal insulin delivery and therapy. Adv. Drug Deliv. Rev. 35:199-234 (1999).

    Google Scholar 

  13. J. Brange, and L. Langkær. In Y. J. Wang, and R. Pearlman (eds.), Stability and Characterization of Protein and Peptide Drugs: Case Histories, Plenum Press, New York, 1993 pp. 315-350.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center for Controlled Chemical Delivery, University of Utah, 30S 2000E RM201, Salt Lake City, Utah, 84112-5820

    Young Jin Kim, Suna Choi, Jae Joon Koh, Minhyung Lee, Kyung Soo Ko & Sung Wan Kim

Authors
  1. Young Jin Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suna Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jae Joon Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Minhyung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kyung Soo Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sung Wan Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, Y.J., Choi, S., Koh, J.J. et al. Controlled Release of Insulin from Injectable Biodegradable Triblock Copolymer. Pharm Res 18, 548–550 (2001). https://doi.org/10.1023/A:1011074915438

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1011074915438

Search

Navigation