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DSC Screening of Potential Prochlorperazine-Excipient Interactions in Preformulation Studies

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Abstract

Differential scanning calorimetry was used to examine the thermal behaviour of mixtures of the drug prochlorperazine with standard excipients, to assess potential interactions, and of mixtures with cyclodextrins, to investigate inclusion complexation which could increase the photostability of the drug. For most of the excipients (magnesium stearate, stearic acid, Explotab®, Ac-Di-Sol®, Encompress® and Ludipress®, lactose and Starch 1500) disappearance or broadening of the melting endotherm of the drug indicated interactions. Lubritab® was the only 'inert' excipient tested. Mixtures of prochlorperazine and the cyclodextrins gave incomplete inclusion complexation as shown by only partial disappearance of the melting endotherm of the drug.

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References

  1. D. C. Monkhouse, Drug Dev. Ind. Pharm., 10 (1984) 1373.

    CAS  Google Scholar 

  2. A. R. Fassihi and P. H. R. Persicaner, Int. J. Pharm., 37 (1987) 167.

    Article  CAS  Google Scholar 

  3. T. Durig and A. R. Fassihi, Int. J. Pharm., 97 (1993) 161.

    Article  CAS  Google Scholar 

  4. J. L. Ford and P. Timmins, Pharmaceutical Thermal Analysis, Ellis Horwood, Chichester, UK 1989.

    Google Scholar 

  5. P. Mura, M. T. Faucci, A. Manderioli, S. Fulanetto and S. Pinzauti, Drug Dev. Ind. Pharm., 24 (1998) 747.

    Article  CAS  Google Scholar 

  6. A. Smith, Anal. Proc., 19 (1982) 559.

    Article  CAS  Google Scholar 

  7. A. A. Van Dooren, Drug Dev. Ind. Pharm., 9 (1983) 43.

    CAS  Google Scholar 

  8. R. E. Gorden, C. L. Van Koevering and D. J. Reits, Int. J. Pharm., 21 (1984) 99.

    Article  Google Scholar 

  9. F. A. Chrzanowsky, L. A. Ulissi, B. J. Fegehy and A. C. Newman, Drug Dev. Ind. Pharm., 12 (1986) 783.

    Google Scholar 

  10. S. Motola and S. Agharkar, in Pharmaceutical Dosage Forms: Parenteral Medications, Vol. 1, (Eds K. E. Avis, L. Lachman and H. A. Lieberman) Dekker, New York 1984, pp. 89–133.

    Google Scholar 

  11. K. A. Connors, G. L. Amidon and V. J. Stella, Chemical Stability of Pharmaceuticals: A Handbook for Pharmacists, 2nd Edn, Wiley, New York 1986, pp. 148–150.

    Google Scholar 

  12. E. M. Antunes, M. Sc. Thesis, Rhodes University, 1998, in preparation.

  13. D. E. Moore and S. R. Tamat, J. Pharm. Pharmacol., 32 (1980) 172.

    CAS  Google Scholar 

  14. J. Sztatisz, S. Gál, J. Kömives, A. Stadler-Szöke and J. Szejtli, Thermal Analysis, Vol. 2, (Ed. W. Hemminger), Birkhaeuser Verlag, Basel 1980, pp. 487–493.

    Google Scholar 

  15. M. E. Brown, M. Lebete, B. D. Glass and E. M. Antunes, in preparation.

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Authors and Affiliations

  1. Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa

    M. E. Brown, E. M. Antunes, B. D. Glass, M. Lebete & R. B. Walker

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  1. M. E. Brown
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  2. E. M. Antunes
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  3. B. D. Glass
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  4. M. Lebete
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  5. R. B. Walker
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Brown, M.E., Antunes, E.M., Glass, B.D. et al. DSC Screening of Potential Prochlorperazine-Excipient Interactions in Preformulation Studies. Journal of Thermal Analysis and Calorimetry 56, 1317–1322 (1999). https://doi.org/10.1023/A:1010150305542

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  • DOI: https://doi.org/10.1023/A:1010150305542

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