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The role of calcium in apoptosis

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Abstract

In this chapter various aspects of apoptosis or programmed cell death (PCD) influenced by calcium as a mediator of signal transduction have been reviewed. Attention has been focused on recently described calcium-binding proteins such as ALG-2 or on a new calcium/calmodulin-dependent kinase, the death asso-ciated protein kinase or DAP-kinase. Both play a central role in apoptotic processes. Calcineurin, which normally is involved in the regulation of T-cell proliferation, is reported to interact with the apoptosis protec-tion protein bcl-2. Its possible involvement in the decision process whether T-cell activation leads to prolif-eration or apoptosis is discussed.© Kluwer Academic Publishers

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  1. Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), Universitaetsstr. 16, CH-8092, Zurich, Switzerland

    Joachim Krebs

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Krebs, J. The role of calcium in apoptosis. Biometals 11, 375–382 (1998). https://doi.org/10.1023/A:1009226316146

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