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Cells in Sol-Gels I: A Cytocompatible Route for the Production of Macroporous Silica Gels

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Abstract

A novel, high hydrolysis ratio sol-gel route for the biocompatible production of macroporous silica gels is presented. This route exploits the two step nature of the gelation reaction to remove undesired alcohol by-products from an acidic aqueous sol prior to gelation. These alcohol-free sols will gel when the pH is raised to the physiologic range in a two-step, acid/base catalyzed process. Furthermore, monolithic macroporous samples can be produced in a controlled manner by introducing water-soluble organic polymers into the sol.

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Authors and Affiliations

  1. Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA, 22903, USA

    John F.T. Conroy, Mary E. Power, Jason Martin, Brian Earp, Bouvard Hosticka & Charles E. Daitch

  2. Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA 22903, USA

    Pamela M. Norris

Authors
  1. John F.T. Conroy
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  2. Mary E. Power
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  3. Jason Martin
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  4. Brian Earp
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  5. Bouvard Hosticka
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  6. Charles E. Daitch
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  7. Pamela M. Norris
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Conroy, J.F., Power, M.E., Martin, J. et al. Cells in Sol-Gels I: A Cytocompatible Route for the Production of Macroporous Silica Gels. Journal of Sol-Gel Science and Technology 18, 269–283 (2000). https://doi.org/10.1023/A:1008704208324

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