Abstract
The ketoprofen/beta-cyclodextrin (β-CD) inclusion compounds may be conveniently obtained through a solid state reaction at room temperature in the presence of saturated water vapour. Relative to the corresponding complexes produced with the usual coprecipitation method, the new compounds have a higher ketoprofen content and/or different properties. In particular, the formation reaction is not accompanied by a loss of hydration water, which is released in distinct stages upon heating. The thermodynamics of the dehydration process is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. Amdidouche, H. Darrouzet, D. Duchene and M. C. Poelman: Int. J. Pharm. 54, 175 (1989).
S. Y. Lin and Y. H. Kao, Int. J. Pharm. 69, 211 (1991).
Y. Nakai, K. Yamamoto, K. Terada, and D. Watanabe: Chem. Pharm. Bull. 35, 4609 (1987).
Y. Nakai, K. Yamamoto, K. Terada, T. Oguchi, H. Saito, and D. Watanabe, Chem. Pharm. Bull. 37, 1055 (1989).
Y. Nakai, K. Yamamoto, T. Oguchi, E. Yonemochi, and T. Hanawa: Chem. Pharm. Bull. 38, 1345 (1990).
Y. Nakai, K. Yamamoto, T. Oguchi, E. Yonemochi, and T. Hanawa, Chem. Pharm. Bull. 39, 1532 (1991).
A. Marini, V. Berbenni, G. Bruni, P.Mustarelli, F. Giordano, and M. Villa, J. Incl. Phenom. 22, 221 (1995).
A. Marini, V. Berbenni, G. Bruni, V. Massarotti, P. Mustarelli and M. Villa, J. Chem. Phys. 103, 7532 (1995).
B. Zhang and R. Breslow, J. Am. Chem. Soc. 115, 9353 (1993).
Y. Inoue, Y. Liu, L. Tong, B. Shen, and D. Jin, J. Am. Chem. Soc. 115, 10637 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bruni, G., Marini, A., Berbenni, V. et al. A Novel Method to Obtain a β-Cyclodextrin Inclusion Compound by Solid State Reaction: the Ketoprofen Case Revisited. Journal of Inclusion Phenomena 35, 517–530 (1999). https://doi.org/10.1023/A:1008020910028
Issue Date:
DOI: https://doi.org/10.1023/A:1008020910028