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Growth Factor Delivery for Tissue Engineering

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Abstract

A tissue-engineered implant is a biologic-biomaterial combination in which some component of tissuehas been combined with a biomaterial to create a device for the restoration or modification of tissue ororgan function. Specific growth factors, released from a delivery device or from co-transplanted cells,would aid in the induction of host paraenchymal cell infiltration and improve engraftment of co-deliveredcells for more efficient tissue regeneration or ameliorate disease states. The characteristic properties ofgrowth factors are described to provide a biological basis for their use in tissue engineered devices. Theprinciples of polymeric device development for therapeutic growth factor delivery in the context of tissueengineering are outlined. A review of experimental evidence illustrates examples of growth factor deliveryfrom devices such as micropaticles, scaffolds, and encapsulated cells, for their use in the applicationareas of musculoskeletal tissue, neural tissue, and hepatic tissue.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Georgia Tech/Emory, Atlanta, Georgia, 30332-0535

    Julia E. Babensee

  2. Department of Bioengineering, Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, 77005

    Larry V. McIntire

  3. Department of Bioengineering, Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, 77005

    Antonios G. Mikos

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Babensee, J.E., McIntire, L.V. & Mikos, A.G. Growth Factor Delivery for Tissue Engineering. Pharm Res 17, 497–504 (2000). https://doi.org/10.1023/A:1007502828372

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