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The Exploitation and Environmental Legacy of Amphibole Asbestos : A Late 20th Century Overview

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Abstract

The risk to human health associated with the inhalation of amphibole asbestos has become devastatingly ap- parent this century. The most commonly utilised asbestiform amphiboles, crocidolite (blue asbestos) and amosite (brown asbestos), are implicated in a variety of diseases related to cell damage within the respiratory tract and adjacent areas. Blue and brown asbestos fibres have a morphology and mineralogy which makes them more biopersistent and biochemically reactive than chrysotile (white asbestos). The long-term pres- ence of such fibres within and around the lungs can result in fibrous scarring, lung cancer, and is the major cause of the once extremely rare tumour known as diffuse malignant mesothelioma. Therefore, despite the fact that asbestiformamphiboles comprise approximately 5%of industrially utilised asbestos (the rest being chrysotile), they have been disproportionately pathogenic. Almost all amphibole asbestos sold on the world market was mined from Palaeoproterozoic ironstones in either the northern Cape Province (blue) or Trans- vaal (brown and blue) areas in South Africa. Production peaked from 1966–1978 when around 2 million tons of crocidolite and1million tons of amosite were produced and exported to be used mainly in asbestos-based cement products and many types of building materials. Crocidolite mixed with chrysotile was commonly used in pressure pipes and gaskets, whereas amosite mixed with chrysotile was especially suitable for gut- ters, roofing, and insulation boards. Amid- to late 20th century amphibole asbestos-related cancer epidemic has consequently struck not only mining and milling communities in producer countries, but many groups of workers (and their relatives and neighbours) exposed to amphibole asbestos-bearing materials in importer countries. Although belated closure and reparation of the mines and imposition of threshold safety limits in the workplace will eventually stem this epidemic the death toll has not yet peaked. Given the long latency period (decades) typical of mesothelioma and bronchogenic carcinoma and the fact that amphibole asbes- tos-bearing materials are still present in some buildings, asbestos-related cancer will inevitably continue to be a major cause of death in many countries worldwide well into the next century.

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References

  • Albin, A., Pooley, F. D., Stromberg, U., Attewell, R., Mitha, R. and Welinder, H., 1994. Retention patterns of asbestos fibres in lung tissue among asbestos cement workers. Occupational and Environmental Medicine, 51, 205–211.

    Google Scholar 

  • Alleman, J. E. and Mossman, B. T., 1997. Asbestos revisited. Scientific American, 277, 54–57.

    Google Scholar 

  • Allison, A. C., 1973. Experimental methods-cell and tissue culture: effects of asbestos particles on macrophages, mesothelial cells and fibroblasts. In: Bogovski, P., Gilson, J. C., Timbrell, V. and Wagner, J. C. (eds.). Biological effects of Asbestos, Proceedings of the Working Conference. Lyon, France, October 1972. International Agency for Research on Cancer Scientific Publication no. 8, 89–93.

  • Berry, G. and Newhouse, M. L., 1983. Mortality of workers manufacturing friction materials using asbestos. British Journal of Industrial Medicine, 40, 1–7.

    Google Scholar 

  • Berry, G., 1991. Prediction of mesothelioma, lung cancer, and asbestosis in former Wittenoom asbestos workers. British Journal of Industrial Medicine, 48, 793–802.

    Google Scholar 

  • BeruBé, K. A., Quinlan, T. R., Moulton, G., Hemenway, D., O'shaugnessy, P., Vacek, P. and Mossman, B. T. 1996a. Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos. Toxicology and applied pharmacology, 137, 67–74.

    Google Scholar 

  • BeruBé, K. A., Quinlan, T. R., Fung, H., Magae, J., Vacek, P., Taatjes, D. J. and Mossman, B. T. 1996b. Apoptosis is observed in mesothelial cells after exposure to crocidolite asbestos. American Journal of Respiratory Cell Molecular Biology, 15, 141–147.

    Google Scholar 

  • Brand, K. G., 1975. Foreign body induced sarcomas. In: Becker, F. F. (ed.), Cancer: A comprehensive treatise. Etiology: Chemical and physical carcinogenesis. New York, Plenum Press, p.485–511.

    Google Scholar 

  • Button, A., 1973. The stratigraphic history of the Malmani Dolomite in the eastern and north-eastern Transvaal. Transactions of the Geological Society of South Africa, 76, 229–247.

    Google Scholar 

  • Coetzee, C. B., Brabers, A. J. M., Malherbe, S. J. and van Biljon, W. J., 1976. Asbestos. In: Coetzee, C. B. (ed.). Mineral Resources of the Republic of South Africa, Geological Survey Handbook no. 7, 261–268.

  • Churg, A., 1983. Asbestos fibre content of the lungs of chrysotile miners with and without asbestos airways disease. American Review of Respiratory Disease 127, 470–473.

    Google Scholar 

  • Churg. A., 1993. Asbestos lung burden and disease patterns in man. In: Guthrie, G. D. Jr. and Mossman, B. T. 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v. 28, 409–426.

    Google Scholar 

  • Churg, A. and Wiggs, B., 1986. Fiber size and number in users of processed chrysotile ore, chrysotile miners, and members of the general population. American Journal of Industrial Medicine, 9, 143–152.

    Google Scholar 

  • Churg, A. and Wright, J., 1989. Fibre content of lung in amphibole vs chrysotile induced mesothelioma: Implications for environmental exposure. In Bignon, J. (ed.), Non-occupational Exposure to Mineral Fibres, IARC, Lyon, 314–318.

    Google Scholar 

  • Churg, A., DePaoli, L., Kempe, B., and Stevens, B., 1984. Lung asbestos content in chrysotile workers with mesothelioma. American Review of Respiratory Disease, 130, 1042–1045.

    Google Scholar 

  • Coffin, D. L., Cook, P. M. and Creason, J. P., 1992. Relative mesothelioma induction in rats by mineral fibers: comparison with residual pulmonary mineral fiber number and epidemiology. Inhalation Toxicology, 4, 273–300.

    Google Scholar 

  • Constantopolous, S. H., Langer, A. M., Saratzis, N. and Nolan, R. P., 1987. Regional findings in Metsovo lung. The Lancet II, 452–453.

    Google Scholar 

  • Doll, R., 1955. Mortality from lung cancer in asbestos workers. British Journal of Industrial Medicine, v.12, 81–86.

    Google Scholar 

  • Doll, R. and Peto, J., 1985. Effects on health exposure to asbestos. U. K. Health and Safety Commission, Her Majesty's Stationary Office.

  • Dreyer, C. J. B., 1982. Amphibole asbestos in South Africa. PhD thesis, Rand Afrikaans University, 313p (unpublished).

  • Dreyer C. J. B. and Sohnge, A. P. G., 1992. The crocidolite and amosite deposits of the Republics of South Africa and Bophuthatswana. Geological Survey of South Africa, Handbook no. 12, 126p.

  • Driscoll, K. E., 1993. In vitro evaluation of mineral cytotoxicity and inflammatory activity. In: Guthrie, G. D. Jr. and Mossman, B. T. (eds.) 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v.28, 489–511.

  • Felix, M. A. 1991. Risking their lives in ignorance-the story of an asbestos polluted community. In: Cock, J. and Koch, E. (eds.) 1991. Going Green: People, Politics and the Environment in South Africa. Oxford University Press, Cape Town, 33–43.

    Google Scholar 

  • Gottardi, G. and Galli, E. 1985. Natural Zeolites. Springer-Verlag, Berlin, 409p.

    Google Scholar 

  • Guthrie, G. D. Jr. and Mossman, B. T. (eds.) 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v.28, 584p.

  • Hall, A. L., 1918. Asbestos in the Union of South Africa. Memoir of the Geological Survey of South Africa, 12, 152p.

  • Harington, J.S, Miller, K. and MacNab, G. 1971. Hemolysis by asbestos. Environmental Research, v.4, 95–117.

    Google Scholar 

  • Hodgson, A. A., 1965. Fibrous silicates. Lecture series Royal Institute of Chemists, London, 4AA, 46p.

    Google Scholar 

  • Hodgson, J. T. and Jones, R. D., 1986. Mortality of asbestos workers in England and Wales 1971–81. British Journal of Industrial Medicine, v.43, 158–164.

    Google Scholar 

  • Hughes, J. M. and Weill, H., 1991. Asbestosis as a precursor of asbestos-related lung cancer: results of a propective mortality study study. British Journal of Industrial Medicine, 48, 229–233.

    Google Scholar 

  • Jaurand, M. C., Gaudichet, A, Halpern, S. and Bignon, S., 1984. In Vitro biodegradation of chrysotile fibres by alveolar macrophages and mesothelial cells in culture: comparison with a pH effect. British Journal of Industrial Medicine, 41, 389–395.

    Google Scholar 

  • Kambic, V., Radšel, Z. and Gale, N., 1991. Alterations in the laryngeol mucosa after exposure to asbestos. British Journal of Industrial Medicine, 46, 717–723.

    Google Scholar 

  • Kensler, T. W., Egner, P. A., Moore, K. G., Taffe, B. G., Twerdok, L. E. and Thrush, M. A., 1987. Role of inflammatory cells in the metabolic act of polycyclic aromatic hydrocarbons in mouse skin. Toxicology & Applied Pharmacology, v.90, 337–346.

    Google Scholar 

  • Lehnert, B. E., 1993. Defense mechanisms against inhaled particles and associated particle-cell interactions. In: Guthrie, G. D. Jr. and Mossman, B. T. 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v.28, 427–469.

    Google Scholar 

  • Langer, A. M., Nolan, R. P. Constantopolous, S. H. and Moutsopoulos, H. M., 1987. Association of Metsovo lung and pleural mesotheliomas with exposure to tremolite-containing whitewash. The Lancet I, 965–967.

    Google Scholar 

  • Lechner, J. F., Tokiwa, T., LaVeck, M., Benedict, W. F., Banks-Schlegel, S., Yeager, H. Jf., Banerjee, A. and Harris, C. C. 1985. Asbestos-associated chromosomal changes in human mesothelial cell. Proceedings of the National Science Academy USA, 82, 3884–3888.

    Google Scholar 

  • Lewis, R. J. Sr., 1992. Sax's dangerous properties of industrial minerals, 8th ed., v.2, 303–305.

    Google Scholar 

  • Magnani, C., Terracini, B., Ivaldi, C., Botta, M., Budel, P., Mancini, A. and Zanotti, R., 1993. A cohort study of mortality among wives of workers in the asbestos cement industry in Casale Monteferrato, Italy. British Journal of Industrial Medicine, 50, 779–784.

    Google Scholar 

  • McConnochie, K., Simonato, L., Mavrides, P., Christofides, P., Pooley, F. D. and Wagner, J. C. 1987. Mesothelioma in Cyprus: the role of tremolite. Thorax, 42, 342–347.

    Google Scholar 

  • McDonald, J. C., Armstrong, B., and Case, B., 1989. Mesothelioma and asbestos fiber type. Evidence from lung tissue analysis. Cancer, 63, 1544–1547.

    Google Scholar 

  • McFadden, D., Wright, J. L., Wiggs, B. and Churg, A., 1986. Cigarette smoke increases the penetration of asbestos fibres into airway wall. American Journal of Pathology, v.123, 95–99.

    Google Scholar 

  • Mossman, B. T., 1993a. Cellular and molecular mechanisms of disease. In: Guthrie, G. D. Jr. and Mossman, B. T. 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v.28, 513–521.

    Google Scholar 

  • Mossman, B. T., 1993b. Mechanisms of asbestos carcinogenesis and toxicity: the amphibole hypothesis revisited. British Journal of Industrial Medicine, 50, 673–676.

    Google Scholar 

  • Newhouse, M. L. and Thompson, H., 1965. Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area. British Journal of Industrial Medicine, 22, 261–269.

    Google Scholar 

  • Nolan, R. P. and Langer, A. M., 1993. Limitations of the Stanton hypothesis. In: Guthrie, G. D. Jr. and Mossman, B. T. 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v.28, 309–326.

    Google Scholar 

  • Pelin, K., Hirvonen, M., Taavitsainen, M and Linnainmaa, K. 1995. Cytogenetic response to asbestos fibers in cultured human primary mesothelial cells from 10 different donors. Mutation Research, 334, 225–233.

    Google Scholar 

  • Peto, J., Hodgson, J. T., Matthews, F. E. and Jones, J. R., 1995. Continuing increase in mesothelioma mortality in Britain. The Lancet, 345, 535–539.

    Google Scholar 

  • Pott, F., Ziem, U., Rieffer, F. J., Huth, F., Ernst, H. and Mohr, U. 1987. Carcinogeneity studies of fibres, metal compounds, and some other dusts in rats. Experimental Pathology (JENA), 32, 19–152.

    Google Scholar 

  • Phillips, B. J., James, T. E. B. and Anderson, D. 1984. Genetic damage in CHO cells exposed to enzymatically generated active oxygen species. Mutation Research, 126, 265–271.

    Google Scholar 

  • Roggli, V. L., Pratt, P. C. and Brody, A. R., 1994. Asbestos fiber type in malignant mesothelioma: An analytical scanning electron microscopic study of 94 cases. American Journal of Industrial Medicine, 23, 605–620.

    Google Scholar 

  • Ross, M. 1981. The geologic occurrences and health hazards of amphible and serpentine asbestos. In: Veblen, D. R. (ed.), Amphiboles and other hydrous pyriboles-Mineralogy. Reviews in Mineralogy, 9A, 279–323.

  • Sebastien, P., Plourde, M. and Robb, R, 1986. Ambient air asbestos survey in Quebec Mining Towns: Part 2-Main Study. Environment Canada Report 5/AP/ RQ-2E.

  • Selikoff, I. J., Churg, J, and Hammond, E. C., 1964. Asbestos exposure and neoplasia. Journal of the American Medical Association, 188, 22–26.

    Google Scholar 

  • Stanton, M. F., Layard, M., Tegeris, A., Miller, E., May, M., Morgan, E. and Smith, A., 1981. Relation of particle dimension to carcinogeneity of amphibole asbestoses and other fibrous minerals. Journal of National Cancer Institute, 67, 965–975.

    Google Scholar 

  • UK Department of Health, 1995. On the state of the public health. Her Majesty's Stationary Office, London, 250 p.

    Google Scholar 

  • Veblen, D. R., 1980. Anthophyllite asbestos: Microstructures, intergrown sheet silicates, and mechanisms of fiber formation. American Mineralogist, 65, 1075–1086.

    Google Scholar 

  • Veblen, D. R. and Wylie, A. G., 1993. In: Guthrie, G. D. Jr. and Mossman, B. T. 1993. Health effects of minerals dusts, Mineralogical Society of America, Reviews in Mineralogy v.28, 61–138.

    Google Scholar 

  • Wagner, J. C., 1991. The discovery of the association between blue asbestos and mesotheliomas and the aftermath. British Journal of Industrial Medicine, 48, 399–403.

    Google Scholar 

  • Wagner, J. C., Berry, G., Skidmore, J. W., and Timbrell, V. 1974. The effects of the inhalation of asbestos in rats. British Journal of Cancer, 29, 252–269.

    Google Scholar 

  • Wagner, J. C., Sleggs, C. A. and Marchand, P., 1960. Diffuse pleural mesothelioma and asbestos exposure in North Western Cape Province. British Journal of Industrial Medicine, v.17, 260–271.

    Google Scholar 

  • Wehner, A. P. and Felton, D-L. (eds.), 1989. Biological interaction of inhaled mineral fibers and cigarette smoke. Columbus, Ohio, Battelle Press, 611 p.

    Google Scholar 

  • Weitzman, S. A. and Stossel, T. P., 1981. Mutation caused by human phagocytes. Science, v. 212, 546–547.

    Google Scholar 

  • Whittaker, E. J. W. 1979. Mineralogy, chemistry and crystallography of amphibole asbestos. In: Ledoux, R. L. (ed.), Mineralogical techniques of asbestos determination. Mineralogical Association of Canada, Montreal, 1–34.

    Google Scholar 

  • Wragg, G. 1995. The Asbestos Time Bomb. Catalyst Press, (Annandale, Australia), 81pp.

    Google Scholar 

  • Wylie, A. G., Shedd, K. B., and Taylor, M. E. 1982. Measurement of the thickness of amphibole asbestos fibres with the scanning electron microscope and the transmission electron microscope. In: Heinrich, K. F., Microbeam Analysis, 181–187. San Francisco Press, San Francisco.

    Google Scholar 

  • Yazicioglu, S., Ilcayto, R., Balci, K., Sayti, B. S., and Yorulmaz, B. 1980. Pleural mesotheliomas and brochial cancers caused by tremolite dust. Thorax, 35, 564–569.

    Google Scholar 

  • Zoltai, T. 1981. Amphibole asbestos mineralogy. In Veblen, D. R. (ed.), Amphiboles and other hydrous pyriboles-Mineralogy. Reviews in Mineralogy, 9A, 237–278.

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Gibbons, W. The Exploitation and Environmental Legacy of Amphibole Asbestos : A Late 20th Century Overview. Environmental Geochemistry and Health 20, 213–230 (1998). https://doi.org/10.1023/A:1006562102206

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