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Paramutation in maize

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Abstract

Paramutation is a heritable change in gene expression induced by allele interactions. This review summarizes key experiments on three maize loci, which undergo paramutation. Similarities and differences between the phenomenology at the three loci are described. In spite of many differences with respect to the stability of the reduced expression states at each locus or whether paramutation correlates with DNA methylation and repeated sequences within the loci, recent experiments are consistent with a common mechanism underlying paramutation at all three loci. Most strikingly, trans-acting mutants have been isolated that prevent paramutation at all three loci and lead to the activation of silenced Mutator transposable elements. Models consistent with the hypothesis that paramutation involves heritable changes in chromatin structure are presented. Several potential roles for paramutation are discussed. These include localizing recombination to low-copy sequences within the genome, establishing and maintaining chromatin domain boundaries, and providing a mechanism for plants to transmit an environmentally influenced expression state to progeny.

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References

  • Argon-Alcaide, L., Miller, T., Schwarzacher, T., Reader, S. and Moore, G. 1996. A cereal centromeric sequence. Chromosoma (Berlin) 105: 261–268.

    PubMed  Google Scholar 

  • Axtell, J.D. and Brink, R.A. 1967. Chemically induced paramutation at the R locus in maize. Proc. Natl. Acad. Sci. USA 58: 181–187.

    PubMed  Google Scholar 

  • Bennetzen, J.L., Schrick, K., Springer, P.S., Brown, W.E. and San-Miguel, P. 1994. Active maize genes are unmodified and flanked by diverse classes of modified, highly repetitive DNA. Genome 37: 565–576.

    PubMed  Google Scholar 

  • Bray, R.A. and Brink, R.A. 1966. Mutation and paramutation at the R locus in maize. Genetics 54: 137–149.

    Google Scholar 

  • Brink, R.A. 1956. A genetic change associated with the R locus in maize which is directed and potentially reversible. Genetics 41: 872–889.

    Google Scholar 

  • Brink, R.A. 1958. Paramutation at the R locus in maize. Cold Spring Harbor Symp. Quant. Biol. 23: 379–391.

    PubMed  Google Scholar 

  • Brink, R.A. 1973. Paramutation. Annu. Rev. Genet. 7: 129–152.

    PubMed  Google Scholar 

  • Brink, R.A. and Mikula, B. 1958. Plant color effects of certain anomalous forms of the Rr allele in maize. Z. Ind. Abst. Vererb. 89: 94–102.

    Google Scholar 

  • Brink, R.A., Brown, D.F., Kermicle, J. and Weyers, W.H. 1960. Locus dependence of the paramutant R phenotype in maize. Genetics 45: 1297–1312.

    Google Scholar 

  • Brink, R.A., Kermicle, J.L. and Ziebur, N.K. 1970. Derepression in the female gametophyte in relation to paramutant R expression in maize endosperms, embryos and seedlings. Genetics 66: 87–96.

    Google Scholar 

  • Brink, R.A., Styles, E.C. and Axtell, J.D. 1968. Paramutation: directed genetic change. Science 159: 161–170.

    PubMed  Google Scholar 

  • Brown, D.G. 1966. Paramutability of Rg and rr mutant genes derived from an Rr allele in maize. Genetics 54: 899–910.

    Google Scholar 

  • Brown, D.G. and Brink, R.A. 1960. Paramutagenic action of paramutant Rr and Rg alleles in maize. Genetics 45: 1313–1316.

    Google Scholar 

  • Brown, J. and Sundaresen, V. 1991. A recombination hotspot in the maize a1 intragenic region. Theor. Appl. Genet. 81: 185–188.

    Google Scholar 

  • Cavalli, G. and Paro, R. 1998. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Cell 93: 505–518.

    PubMed  Google Scholar 

  • Chandler, V.L., Kubo, K. M. and Hollick, J. B. 1996. b and pl paramutation in maize: heritable transcription states programmed during development. In: V. Russo, R. Martienssen and A.D. Riggs (Eds.) Epigenetic Mechanisms of Gene Regulation, Cold Spring Harbor Press, Cold Spring Harbor, NY, pp. 289–304.

    Google Scholar 

  • Civardi, L., Xia, Y., Edward, K.J., Schnable, P.S. and Nikolau, B.J. 1994. The relationship between genetic and physical distances in the cloned a1–sh2 interval of the Zea mays L. genome. Proc. Natl. Acad. Sci. USA 91: 8268–8272.

    PubMed  Google Scholar 

  • Cocciolone, S.M. and Cone, K.C. 1993. Pl-Bh, an anthocyanin regulatory gene of maize that leads to variegated pigmentation. Genetics 135: 575–588.

    PubMed  Google Scholar 

  • Coe, E.H., Jr. 1959. A regular and continuing conversion-type phenomenon at the B locus in maize. Proc. Natl. Acad. Sci. USA 45: 828–832.

    Google Scholar 

  • Coe, E.H., Jr. 1966. The properties, origin, and mechanism of conversion-type inheritance at the B locus in maize. Genetics 53: 1035–1063.

    Google Scholar 

  • Coe, E.H., Jr. 1979. Specification of the anthocyanin biosynthetic function by b and r in maize. Maydica 24: 49–58.

    Google Scholar 

  • Colot, V. and Rossignol, J.L. 1999. Eukaryotic DNA methylation as an evolutionary force. Bioessays 21: 402–411.

    PubMed  Google Scholar 

  • Colot, V., Maloisel, L. and Rossignol, J.L. 1996. Interchromosomal transfer of epigenetic states in Ascobulus: transfer of DNA methylation is mechanistically related to homologous recombination. Cell 86: 855–864.

    Google Scholar 

  • Cone, K.C., Cocciolone, S. M., Burr, F.A. and Burr, B. 1993. Maize anthocyanin regulatory gene pl is a duplicate of c1 that functions in the plant. Plant Cell 5: 1795–1805.

    PubMed  Google Scholar 

  • Csink, A.K. and Henikoff, S. 1996. Genetic modifications of heterochromatic associations and nuclear organization in Drosophila. Nature 381: 529–531.

    PubMed  Google Scholar 

  • Das, O.P. and Messing, J. 1994. Variegated phenotype and developmental methylation changes of a maize allele originating from epimutation. Genetics 136: 1121–1141.

    PubMed  Google Scholar 

  • DeCarvalho, F., Gheysen, G., Kushnir, S., Van Montagu, M., Inzé, D. and Castresana, C. 1992. Suppression of β-1,3–glucanase transgene expression in homozygous plants. EMBO J. 11: 2595–2602.

    PubMed  Google Scholar 

  • Dooner, H.K. 1979. Identification of an R-locus region that controls the tissue specificity of anthocyanin formation inmaize. Genetics 93: 703–710.

    Google Scholar 

  • Dooner, H.K. and Kermicle, J.L. 1976. Displaced and tandem duplications in the long arm of chromosome 10 in maize. Genetics 82: 309–322.

    Google Scholar 

  • Dooner, H.K. and Martínez-Férez, I.M. 1997. Recombination occurs uniformly within the bronze gene, a meiotic recombination hotspot in the maize genome. Plant Cell 9: 1633–1646.

    PubMed  Google Scholar 

  • Dooner, H.K., Weck, E., Adams, S., Ralston, E., Favreau, M. and English, J. 1985. A molecular genetic analysis of insertions in the bronze locus in maize. Mol. Gen. Genet. 200: 240–246.

    Google Scholar 

  • Dooner, H.K., Robbins, T.P. and Jorgensen, R.A. 1991. Genetic and developmental control of anthocyanin biosynthesis. Annu. Rev. Genet. 25: 173–199.

    Google Scholar 

  • Dreesen, T.D., Henikoff, S. and Loughney, K. 1991. A pairingsensitive element that mediates trans-inactivation associated with the Drosophila brown gene. Genes Dev. 5: 331–340.

    PubMed  Google Scholar 

  • Eggleston, W., Alleman, M. and Kermicle, J.L. 1995. Molecular organization and germinal instability of R-stippled maize. Genetics 141: 347–360.

    PubMed  Google Scholar 

  • Ekwall, K., Olsson, T., Turner, B.M., Cranston, G. and Allshire, R.C. 1997. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres. Cell 91: 1021–1032.

    PubMed  Google Scholar 

  • Finnegan, E.J., Peacock, W.J. and Dennis, E.S. 1996. Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development. Proc. Natl. Acad. Sci. USA 93: 8449–8454.

    PubMed  Google Scholar 

  • Gaut, B.S. and Doebley, J.F. 1997. DNA sequence evidence for the segmental allotetraploid origin of maize. Proc. Natl. Acad. Sci. USA 94: 6809–6814.

    PubMed  Google Scholar 

  • Geyer, P.K., Green, M.M. and Corces, V.G. 1990. Tissue-specific transcriptional enhancers may act in trans on the gene located in the homologous chromsome: the molecular basis of transvection in Drosophila. EMBO J. 9: 2247–2256.

    PubMed  Google Scholar 

  • Goff, S.A., Klein, T.M., Roth, B.A., Fromm, M.E., Cone, K.C. and Chandler, V.L. 1990. Trans-activation of anthocyanin biosynthetic genes following transfer of b regulatory genes into maize tissues. EMBO J. 9: 2517–2522.

    PubMed  Google Scholar 

  • Goff, S.A., Cone, K.C. and Chandler, V.L. 1992. Functional analysis of the transcriptional activator encoded by the maize B gene: evidence for a direct functional interaction between two classes of regulatory proteins. Genes Dev. 6: 864–875.

    PubMed  Google Scholar 

  • Grewal, S.I.S. and Klar, A.J.S. 1996. Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis. Cell 86: 95–101.

    PubMed  Google Scholar 

  • Grotewold, E., Athma, P. and Peterson, T. 1991. Alternatively spliced products of the maize P gene encode proteins with homology to the DNA binding domain of Myb-like transcription factors. Proc. Natl. Acad. Sci. USA 88: 4587–4591.

    PubMed  Google Scholar 

  • Grotewold, E., Drummond, B., Bowen, B. and Peterson, T. 1994. The Myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Cell 76: 543–553.

    Article  PubMed  Google Scholar 

  • Heard, E., Clerc, P. and Avner, P. 1997. X-chromosome inactivation in mammals. Annu. Rev. Genet. 31: 571–610.

    PubMed  Google Scholar 

  • Henikoff, S. 1998. Conspiracy of silence among repeated transgenes. BioEssays 20: 532–535.

    PubMed  Google Scholar 

  • Henikoff, S. and Comai, L. 1998. Trans-sensing effects: the ups and downs of being together. Cell 93: 329–332.

    PubMed  Google Scholar 

  • Hoekenga, O. 1998. Epigenetic regulation of Pl-Blotched. Ph.D. dissertation, University of Missouri, Columbia, MO.

    Google Scholar 

  • Hollick, J.B. and Chandler, V.L. 1998. Epigenetic allelic states of a maize transcriptional regulatory locus exhibit overdominant gene action. Genetics 150: 891–897.

    PubMed  Google Scholar 

  • Hollick, J.B., Patterson, G.I., Coe, E.H. Jr., Cone, K.C. and Chandler, V. L. 1995. Allelic interactions heritably alter the activity of a metastable maize pl1 allele. Genetics 141: 709–719.

    PubMed  Google Scholar 

  • Hollick, J.B., Dorweiler, J.E. and Chandler, V.L. 1997. Paramutation and related allelic interactions. Trends Genet. 13: 302–308

    PubMed  Google Scholar 

  • Hollick, J.B., Patterson, G.I., Asmundsson, I.M. and Chandler, V.L. 2000. Paramutation alters regulatory control of the maize pl1 locus. Genetics, 154: 1827–1838.

    PubMed  Google Scholar 

  • Ingelbrecht, I., Van Houdt, H., Van Montagu, M. and Depicker, A. 1994. Post-transcriptional silencing of reporter transgenes in tobacco correlates with DNA methylation. Proc. Natl. Acad. Sci. USA 91: 10502–10506.

    PubMed  Google Scholar 

  • Jeddeloh, J.A., Stokes, T.L. and Richards, E.J. 1999. Maintenance of genomic methylation requires a SWI2/SNF2–like protein. Nature Genet. 22: 94–97.

    PubMed  Google Scholar 

  • Jorgensen, R.A. 1995. Cosuppression, flower color patterns, and metastable gene expression states. Science 268: 686–691.

    Google Scholar 

  • Kermicle, J. L. 1996. Epigenetic silencing and activation of a maize r gene. In: V.E.A. Russo, R.A. Martienssen and A.D. Riggs (Eds) Epigenetic Mechanisms of Gene Regulation, Cold Spring Harbor Laboratory Press, Plainview, NY, pp. 267–287.

    Google Scholar 

  • Kermicle, J.L. and Axtell, J.D. 1981. Modification of chlorophyll striping by the R region. Maydica 26: 185–197.

    Google Scholar 

  • Kermicle, J.L., Eggleston W.B. and Alleman, M. 1995. Organization of paramutagenicity in R-stippled maize. Genetics 141: 361–372.

    PubMed  Google Scholar 

  • Klar, A.J.S. 1998. Propagating epigenetic states through meiosis: where Mendel's gene is more than a DNA moiety. Trends Genet. 14: 299–301.

    PubMed  Google Scholar 

  • Krebbers, E., Hehl, R., Piotrowiak, R., Lonnig, W., Sommer, H. and Saedler, H. 1987. Molecular analysis of paramutant plants of Antirrhinum majus and the involvement of transposable elements. Mol. Gen. Genet. 214: 325–327.

    Google Scholar 

  • Lechelt, C., Peterson, T., Laird, A., Chen, J., Dellaporta, S., Dennis, E., Peacock, W.J. and Starlinger, P. 1989. Isolation and molecular analysis of the maize P locus. Mol. Gen. Genet. 219: 225–234.

    PubMed  Google Scholar 

  • Lee, J.T. and Jaenisch, R. 1997. Long-range cis effects of ectopic Xinactivation centers on a mouse autosome. Nature 386: 275–279.

    PubMed  Google Scholar 

  • Lee, J.T., Strauss, W.M., Dausman, J.A. and Jaenisch, R. 1996. A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell 86: 83–94.

    PubMed  Google Scholar 

  • Ludwig, S.R., Bowen, B., Beach, L. and Wessler, S. 1990. A regulatory gene as a novel visible marker for maize transformation. Science 247: 449–450.

    Google Scholar 

  • Ludwig, S.R. and Wessler, S.R. 1990. Maize R gene family: tissuespecific helix-loop-helix proteins. Cell 62: 849–851.

    PubMed  Google Scholar 

  • Lund, G., Das, O.P. and Messing, J. 1995. Tissue-specific DNaseIsensitive sites of the maize P gene and their changes upon epimutation. Plant J. 7: 797–807.

    Google Scholar 

  • Maloisel, L. and Rossignol, J.L. 1998. Suppression of crossing-over by DNA methylation in Ascobolus. Genes Dev. 12: 1381–1389.

    PubMed  Google Scholar 

  • Martienssen, R.A. 1996. Epigenetic silencing of Mu transposable elements in maize. In: V.E.A. Russo, R.A. Martienssen and A.D. Riggs (Eds) Epigenetic Mechanisms of Gene Regulation, Cold Spring Harbor Laboratory Press, Plainview, NY, pp. 593–608.

    Google Scholar 

  • Matzke, M.A., Matzke, A.J.M. and Eggleston, W.B. 1996. Paramutation and transgene silencing: a common response to invasive DNA? Trends Plant Sci. 1: 382–388.

    Google Scholar 

  • Matzke, A.J.M., Neuhuber, F., Park, Y.-D., Ambros, D.F. and Matzke, M.A. 1994. Homology-dependent gene silencing in transgenic plants, epistatic silencing loci contain multiple copies of methylated transgenes. Mol. Gen. Genet. 244: 219–229.

    PubMed  Google Scholar 

  • McClintock, B. 1965. The control of gene action in maize. Brookhaven Symp. Biol. 18: 162–184.

    Google Scholar 

  • McWhirter, K.S. and Brink, R.A. 1962. Continuous variation in level of paramutation at the R locus in maize. Genetics 47: 1053–1074.

    Google Scholar 

  • Meyer, P., Heidmann, I. and Niedenhoff, I. 1993. Differences in DNA methylation are associated with a paramutation phenomenon in transgenic petunia. Plant J. 4: 89–100.

    PubMed  Google Scholar 

  • Meyer, P., Linn, F., Heidmann, I., Meyer, Z.A.H., Niedenhof, I. and Saedler, H. 1992. Endogenous and environmental factors influence 35S promoter methylation of a maize A1-gene construct in transgenic petunia and its colour phenotype. Mol. Gen. Genet. 231: 345–352.

    PubMed  Google Scholar 

  • Mikula, B.C. 1961. Progressive conversion of R-locus expression in maize. Proc. Natl. Acad. Sci. USA 47: 566–571.

    PubMed  Google Scholar 

  • Mikula, B.C. 1967. Heritable changes in R-locus expression in maize is responsive to environment. Genetics 56: 733–742.

    Google Scholar 

  • Mikula, B.C. 1995. Environmental programming of heritable epigenetic changes in paramutant r-gene expression using temperature and light at a specific stage of early development in maize seedlings. Genetics 140: 1379–1387.

    PubMed  Google Scholar 

  • Neal, K.C. 1998. Characterization of the organization and paramutagenicity of the maize R-marbled allele. M.S. dissertation, Virginia Commonwealth University, Richmond, VA.

    Google Scholar 

  • Panavas, T., Weir, J. and Walker, E.L. 1999. The structure and paramutagenicity of the R-marbled haplotype in Zea mays. Genetics 153: 979–991.

    PubMed  Google Scholar 

  • Panning, B. and Jaenisch, R. 1998. RNA and the epigenetic regulation of X chromosome inactivation. Cell 93: 305–308.

    PubMed  Google Scholar 

  • Patterson, G.I. and Chandler, V.L. 1995. Timing of b locus paramutation. Maydica 40: 35–41.

    Google Scholar 

  • Patterson, G.I., Harris, L.J., Walbot, V. and Chandler, V.L. 1991. Genetic analysis of B-Peru, a regulatory gene in maize. Genetics 126: 205–220.

    Google Scholar 

  • Patterson, G.I., Thorpe, C.J. and Chandler, V.L. 1993. Paramutation, an allelic interaction, is associated with a stable and heritable reduction of transcription of the maize b regulatory gene. Genetics 135: 881–894.

    PubMed  Google Scholar 

  • Patterson, G.I., Kubo, K.M., Shroyer, T. and Chandler, V.L. 1995. Sequences required for paramutation of the maize b gene map to a region containing the promoter and upstream sequences. Genetics 140: 1389–1406.

    PubMed  Google Scholar 

  • Penny, G.D., Kay, G.F., Sheardown, S.A., Rastan, S. and Brockdorff, N. 1996. Requirement for Xist in X chromosome inactivation. Nature 379: 131–137.

    Article  PubMed  Google Scholar 

  • Pirrotta, V. 1997. PcG complexes and chromatin silencing. Curr. Opin. Genet. Dev. 7: 249–258.

    PubMed  Google Scholar 

  • Pirrotta, V. 1998. Polycombing the genome: PcG, trxG and chromatin silencing. Cell 93: 333–336.

    PubMed  Google Scholar 

  • Quinn, A.R. 1999. Characterization of the transposable element responsible for germinal and somatic instability of the maize R-marbled allele. M.S. dissertation, Virginia Commonwealth University, Richmond, VA.

    Google Scholar 

  • Radicella, J.P., Turks, D. and Chandler, V.L. 1991. Cloning and nucleotide sequence of a cDNA encoding B-Peru, a regulatory protein of the anthocyanin pathway in maize. Plant Mol. Biol. 17: 127–130.

    PubMed  Google Scholar 

  • Radicella, J.P., Brown, D., Tolar, L.A. and Chandler, V.L. 1992. Allelic diversity of the maize b regulatory gene: different leader and promoter sequences of two b alleles determine distinct tissue specificities of anthocyanin production. Genes Dev. 6: 2152–2164.

    PubMed  Google Scholar 

  • Robbins, T.P., Walker, E.L., Kermicle, J.L., Alleman, M. and Dellaporta, S.L. 1991. Meiotic instability of the R-r complex arising from displaced intragenic exchange and intrachromosomal rearrangement. Genetics 129: 217–283.

    Google Scholar 

  • Sastry, G.R.K., Cooper, H.B., Jr. and Brink, R.A. 1965. Paramutation and somatic mosaicism in maize. Genetics 52: 407–424.

    PubMed  Google Scholar 

  • Schwartz, D.C. and Cantor, C.R. 1984. Separation of yeast chromosome-sized DNAs by pulsed-field gel gradient electrophoresis. Cell 37: 67–75.

    Article  PubMed  Google Scholar 

  • Selinger, D.A. and Chandler, V.L. 1999. Major recent and independent changes in levels and patterns of expression have occurred at the b gene, a regulatory locus in maize. Proc. Natl. Acad. Sci. USA 96: 15007–15012.

    PubMed  Google Scholar 

  • Selinger, D.A., Lisch, D. and Chandler, V.L. 1998. The maize regulatory gene, B-Peru, contains a DNA rearrangement that specifies tissue-specific expression through both positive and negative promoter elements. Genetics 149: 1125–1138.

    PubMed  Google Scholar 

  • Selker, E.U. 1997. Epigenetic phenomena in filamentous fungi: useful paradigms or repeat-induced confusion? Trends Genet. 13: 293–341.

    PubMed  Google Scholar 

  • Sherman, J. M. and Pillus, L. 1997. An uncertain silence. Trends Genet. 13: 308–313.

    PubMed  Google Scholar 

  • Shih, K.L. and Brink, R.A. 1969. Effects of X-irradiation on aleurone pigmenting potential of standard Rr and a paramutant form of Rr in maize. Genetics 61: 167–177.

    PubMed  Google Scholar 

  • Shore, D. 1995. Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae. In: E.H. Blackburn and C.W. Greider (Eds) Telomeres, Cold Spring Harbor Laboratory Press, Plainview, NY, pp. 139–191.

    Google Scholar 

  • Sidorenko, L., Li, X., Tagliani, L., Bowen, B. and Peterson, T. 1999. Characterization of the regulatory elements of the maize P-rr gene by transient expression assays. Plant Mol. Biol. 39: 11–19.

    PubMed  Google Scholar 

  • Smolik-Utlaut, S. and Gelbart, W.M. 1987. The effects of chromosomal rearrangements on zeste-white interaction in Drosophila melanogaster. Genetics 116: 285–298.

    PubMed  Google Scholar 

  • Stam, M., Lavin, M.T. and Chandler, V.L. 2000. Npi402 and ncsu1 are identical; inra1(tmp) maps upstream of the b promoter. Maize Genet. Coop. Newsl. 74, in press.

  • Stam, M., de Bruin, R., Kenter, S., van der Hoorn, R.A.L., van Blokland, R., Mol, J.N.M. and Kooter, J.M. 1997. Post-transcriptional silencing of chalcone synthase in Petunia by inverted transgene repeats. Plant J. 12: 63–82.

    Google Scholar 

  • Steinmuller, K. and Apel, K. 1986. A simple and efficient procedure for isolating plant chromatin which is suitable for studies of DNase I sensitive domains and hypersensitive sites. Plant Mol. Biol. 7: 87–94.

    Google Scholar 

  • Styles, E.D. and Brink, R.A. 1966. The metastable nature of paramutable R alleles in maize. I. Heritable enhancement in level of standard Rr action. Genetics 54: 433–439.

    Google Scholar 

  • Styles, E.D. and Brink, R.A. 1969. The metastable nature of paramutable R alleles in maize. IV. Parallel enhancement of R action in heterozygotes with r and in hemizygotes. Genetics 61: 801–811.

    Google Scholar 

  • Styles, E.D. and Ceska, O. 1977. The genetic control of flavonoid synthesis in maize. Can. J. Genet. Cytol. 19: 3019–3021.

    Google Scholar 

  • Styles, E.D., Ceska, O. and Seah, K.T. 1973. Developmental differences in action of r and b alleles in maize. Can. J. Genet. Cytol. 15: 59–72.

    Google Scholar 

  • Thuriax, P. 1977. Is recombination confined to structural genes on the eukaryotic genome? Nature 268: 460–462.

    PubMed  Google Scholar 

  • van Blokland, R., ten Lohuis, M. and Meyer, P. 1997. Condensation of chromatin in transcriptional regions of an inactivated plant transgene: evidence for an active role of transcription in gene silencing. Mol. Gen. Genet. 257: 1–13.

    PubMed  Google Scholar 

  • van Houwelingen, A., Souer, E., Mol, J. and Koes, R. 1999. Epigenetic interactions among three dTph1 transposons in two homologous chromosomes activate a new excision-repair mechanism in Petunia. Plant Cell 11: 1319–1336.

    PubMed  Google Scholar 

  • van West, P., Kamoun, S., van 't Klooster, J.W. and Govers, F. 1999. Internuclear gene silencing in Phytophthora infestans. Mol. Cell 3: 339–348.

    PubMed  Google Scholar 

  • Vaucheret, H. 1993. Identification of a general silencer for 19S and 35S promoters in a transgenic tobacco plant: 90 bp of homology in the promoter sequences are sufficient for trans-inactivation. C. R. Acad. Sci. Paris: 317: 310–323.

    Google Scholar 

  • Vaucheret, H., Beclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.-B., Mourrain, P., Palauqui, J.-C. and Vernhetter, S. 1998. Transgene-induced gene silencing in plants. Plant J: 651–659.

  • Vongs, A., Kakutani, T., Martienssen, R., and Richards, E.J. 1993. Arabidopsis thaliana DNA methylation mutants. Science 260: 926–1928.

    PubMed  Google Scholar 

  • Wakimoto, B.T. 1998. Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila. Cell 93: 321–324.

    PubMed  Google Scholar 

  • Walker, E.L., Robbins, T.P., Bureau, T.E., Kermicle, J. and Dellaporta, S.L. 1995. Transposon-mediated chromosomal rearrangements and gene duplications in the formation of the maize R-r complex. EMBO J. 14: 2350–2363.

    PubMed  Google Scholar 

  • Walker, E. 1998. Paramutation of the r1 locus of maize is associated with increased cytosine methylation. Genetics 148: 1973–1981.

    PubMed  Google Scholar 

  • Williams, W.M. 1972. Variability of the R-stippled gene in maize. Ph.D. dissertation, University of Wisconsin, Madison, WI.

    Google Scholar 

  • Wolffe, A.P. and Matzke, M. A. 1999. Epigenetics: regulation through repression. Science 286: 481–486.

    PubMed  Google Scholar 

  • Yoder, J.A., Walsh, C.P. and Bestor, T.H. 1997. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13: 335–340.

    PubMed  Google Scholar 

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  1. Department of Plant Sciences, University of Arizona, Tucson, AZ , 85721, USA

    Vicki L. Chandler & Jane E. Dorweiler

  2. Department of Biology, Virginia Commonwealth University, Richmond, VA , 23284, USA

    William B. Eggleston

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Chandler, V.L., Eggleston, W.B. & Dorweiler, J.E. Paramutation in maize. Plant Mol Biol 43, 121–145 (2000). https://doi.org/10.1023/A:1006499808317

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