Abstract
Fourteen patients with brain metastases (BM) of solidtumors received intravenous cisplatinum, 40 mg/m2/day, and etoposide,150 mg/m2/day, for 3 days every 3 weeks.Primary tumors were lung (8 patients), breast (4),colon (1), and stomach (1). Two patients responded(1 complete response in a poorly differentiated lungcancer patient and 1 partial response in abreast cancer patient). The overall response rate was14%, with a median survival of 6 months.Main toxicity was grade 3–4 neutropenia that occurredin 36% of patients. There were no toxic-relateddeaths. Chemotherapy as a single therapeutic regimen seemsnot to be an effective treatment for BMfrom relatively resistant solid tumors. Moreover, it producesrather high, although not life-threatening, hematologic toxicity.
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Viñolas, N., Graus, F., Mellado, B. et al. Phase II trial of cisplatinum and etoposide in brain metastases of solid tumors. J Neurooncol 35, 145–148 (1997). https://doi.org/10.1023/A:1005835430489
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DOI: https://doi.org/10.1023/A:1005835430489