Conference Reports
Novel Approaches for Oral Delivery of Macromolecules

https://doi.org/10.1021/js980076hGet rights and content

Abstract

Traditional forms of administrations of nonabsorbable drugs and peptides often rely on their parenteral injection, since the intestinal epithelium is poorly permeable to these therapeutical agents. A number of innovative drug delivery approaches have been recently developed, including the drug entrapment within small vesicles or their passage through the intestinal paracellular pathway. Zonula occludens toxin, a recently discovered protein elaborated by Vibrio cholerae, provided tools to gain more insights on the pathophysiology of the regulation of intestinal permeability through the paracellular pathway and to develop alternative approaches for the oral delivery of drugs and macromolecules normally not absorbed through the intestine.

References and Notes (53)

  • C. Michel et al.

    The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanoparticles in diabetic rats

    J. Pharm. Pharmacol.

    (1991)
  • M.E. Le Fevre et al.

    Intestinal toxicology

  • J.P. Ebel

    A method to quantify particle absorption from the small intestine of the mouse

    Pharm. Res.

    (1990)
  • J. Kreuter

    Nanoparticles

  • N.W. Thomas et al.

    Particle uptake and translocation across epithelial membranes

    J. Anat.

    (1996)
  • J. Pappo et al.

    Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake

    Clin. Exp. Immunol.

    (1989)
  • M.E. Le Fevre et al.

    Proc. Soc. Exp. Biol. Med.

    (1989)
  • P.U. Jani et al.

    Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency

    J. Pharm. Phar-macol.

    (1990)
  • J. Eyles et al.

    Pharm. Pharmacol.

    (1992)
  • D.T. O'Hagan

    The intestinal uptake of particles and the implications for drug and antgen delivery

    J. Anat.

    (1996)
  • D.H. Jones

    Protection of mice from Bordetella pertussis respiratory infection using orally administered microincap-sulated pertussis fimbriae

    Infect. Immun.

    (1996)
  • Z. Moldovenwanu et al.

    Oral immunization with influenza virus in biodegradable microspheres

    J. Infect. Dis.

    (1993)
  • R. Ray

    Microincapsulated human parainfluenza virus induces a protective immune response

    J. Infect. Dis.

    (1993)
  • S.J. Challacombe et al.

    Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen

    Immunology

    (1992)
  • F.A. Klipstein et al.

    Peroral immunization with Escherichia coli heat-labile enterotoxin delivered by microspheres

    Infect. Immun.

    (1983)
  • T.L. Bowerstock

    The potential use of poly (methacrylic acid) hydrogels for oral administration of drugs and vaccines in ruminants

    J. Contolled Rel.

    (1994)
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