Mechanistic Evaluation of Binary Effects of Magnesium Stearate and Talc as Dissolution Retardants at 85% Drug Loading in an Experimental Extended-Release Formulation
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A systematic evaluation of poloxamers as tablet lubricants
2020, International Journal of PharmaceuticsCitation Excerpt :Tableting performance of plastic materials lubricated with MgSt is affected by mixing time (Kikuta and Kitamori, 1994), mixing intensity (Dun and Sun, unpublished), as well as compaction speed (Sun, 2011, 2015). Additionally, the use of MgSt may reduce dissolution of drugs (Chowhan and Chi, 1986; Dürig and Fassihi, 1997; Fukui et al., 2001; Uchimoto et al., 2011), because the hydrophobic MgSt can significantly lower the wettability in an aqueous medium. Lastly, physical properties of MgSt are highly variable (Delaney et al., 2017), depending on its origin (Andrès et al., 2001), crystal form and impurities (Barra and Somma, 1996; Leinonen et al., 1992; Wada and Matsubara, 1994).
Compatibility study of rosmarinic acid with excipients used in pharmaceutical solid dosage forms using thermal and non-thermal techniques
2019, Saudi Pharmaceutical JournalCitation Excerpt :Interactions between RA and TALC were demonstrated by FTIR spectra, suggestive of adsorption effect, and did not promote chemical degradation on RA by ssNMR and IST. Despite the adsorption of drug on excipient surface in pharmaceutical solid form can affect the drug release, influencing in its activity or bioavailability, according to literature, TALC do not promote significant changes on drug release (Dürig and Fassihi, 1997; Panakanti and Narang, 2012). MgSTE and CCS play as the most critical excipients to the development of pharmaceutical dosage forms with RA, since they presented chemical incompatibility in IST assay.
Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media
2018, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Improved dissolution is attributed to reduced particle size and consequently higher surface area and better contact of the micronised drug with the dissolution medium [27]. Although co-grinding of drugs with several excipients, such as lactose monohydrate [28] and avicel [29] accelerated their dissolution profile, there are cases when co-grinding may be used to prolong dissolution and lead to a sustained release profile [30]. A study with theophylline, a hydrophilic compound with log P value similar (log P = −0.02 [31]) to the above drugs, demonstrated that co-grinding with magnesium stearate decreased the dissolution efficiency and mean dissolution rate of the formulation [32] in comparison to a physical mixture of the same powder quantities.
Towards better process understanding: Chemometrics and multivariate measurements in manufacturing of solid dosage forms
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