Advancing Biocapture Substrates via Chemical Lift-Off Lithography

Cao, Huan H.; Nakatsuka, Nako; Liao, Wei-Ssu; Serino, Andrew C.; Cheunkar, Sarawut; Yang, Hongyan; Weiss, Paul S.; Andrews, Anne M.

doi:10.1021/acs.chemmater.7b01970

Title: Advancing Biocapture Substrates via Chemical Lift-Off Lithography

Journal Article · Fri Aug 11 00:00:00 EDT 2017 · Chemistry of Materials

DOI:https://doi.org/10.1021/acs.chemmater.7b01970· OSTI ID:1418547

Cao, Huan H. ^[1];

^[1];

^[1]; Cheunkar, Sarawut ^[1]; Yang, Hongyan ^[2];

^[1];

^[3]

Univ. of California, Los Angeles, CA (United States). California NanoSystems Inst.
Univ. of California, Los Angeles, CA (United States). Semel Inst. for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology
Univ. of California, Los Angeles, CA (United States). California NanoSystems Inst., Semel Inst. for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology

Creating small-molecule-functionalized platforms for high-throughput screening or biosensing applications requires precise placement of probes on solid substrates and the ability to capture and to sort targets from multicomponent samples. Here, chemical lift-off lithography was used to fabricate large-area, high-fidelity patterns of small-molecule probes. Lift-off lithography enables biotin–streptavidin patterned recognition with feature sizes ranging from micrometers to below 30 nm. Subtractive patterning via lift-off facilitated insertion of a different type of molecule and, thus, multiplexed side-by-side placement of small-molecule probes such that binding partners were directed to cognate probes from solution. Small molecules mimicking endogenous neurotransmitters were patterned using lift-off lithography to capture native membrane-associated receptors. Here, we characterized patterning of alkanethiols that self-assemble on Au having different terminal functional groups to expand the library of molecules amenable to lift-off lithography enabling a wide range of functionalization chemistries for use with this simple and versatile patterning method.

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Research Organization:: Univ. of California, Los Angeles, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI ID:: 1418547

Journal Information:: Chemistry of Materials, Vol. 29, Issue 16; ISSN 0897-4756

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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