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What is a randomised controlled trial?

Published online by Cambridge University Press:  11 April 2011

Andrea Cipriani  and
John R. Geddes
Andrea Cipriani*
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona(Italy)
John R. Geddes
Affiliation:
Department of Psychiatry, University of Oxford (United Kingdom)
*
Address for correspondence: Dr. A. Cipriani, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, PiazzaleL.A. Scuro 10, 37134 Verona (Italy). Fax: +39-045-8027498 E-mail: andrea.cipriani@univr.it
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Abstract

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Keywords

Randomized controlled trialmeta-analysisstatisticsrandomizationblinding
Type
ABC of Methodology
Information
Epidemiology and Psychiatric Sciences , Volume 18 , Issue 3 , September 2009 , pp. 191 - 194
Copyright
Copyright © Cambridge University Press 2009

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References

REFERENCES

Cipriani, A., Nosè, M. & Barbui, C. (2008). Allocation concealment and blinding in clinical trials. Epidemiologia e Psichiatria Sociale 17, 115–116.CrossRefGoogle ScholarPubMed
Cipriani, A., Purgato, M. & Barbui, C. (2009). Why internal and external validity of experimental studies are relevant for clinical practice? Epidemiologia e Psichiatria Sociale 18, 101–103.CrossRefGoogle ScholarPubMed
Pablos-Méndez, A., Barr, R.G. & Shea, S. (1998). Run-in Periods in Randomized Trials Implications for the Application of Results in Clinical Practice. Journal of the American Medical Association 279, 222–225.CrossRefGoogle ScholarPubMed
Schulz, K.F., Chalmers, I., Haynes, R.J. & Altman, D.G. (1995). Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. Journal of the American Medical Association 273, 408–412.CrossRefGoogle ScholarPubMed