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Depression and disability in Parkinson's disease: a follow-up of 132 cases

Published online by Cambridge University Press:  09 July 2009

R. G. Brown ,
B. Maccarthy ,
A.-M. Gotham ,
G. J. Der  and
C. D. Marsden
R. G. Brown*
Affiliation:
MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre and MRC Social Psychiatry Unit, Institute of Psychiatry, London
B. Maccarthy
Affiliation:
MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre and MRC Social Psychiatry Unit, Institute of Psychiatry, London
A.-M. Gotham
Affiliation:
MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre and MRC Social Psychiatry Unit, Institute of Psychiatry, London
G. J. Der
Affiliation:
MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre and MRC Social Psychiatry Unit, Institute of Psychiatry, London
C. D. Marsden
Affiliation:
MRC Movement Disorder Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre and MRC Social Psychiatry Unit, Institute of Psychiatry, London
*
1Address for correspondence: Mr R. G. Brown, Department of Neurology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.
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Synopsis

Patients with Parkinson's disease, 132 in number, were followed up after approximately one year, and measures of depression and disability re-administered. Depression was common on both occasions, and was characterized by dysphoria, pessimism and somatic symptoms, but not guilt or self-blame. Depression and disability were associated on both occasions. The relationship between changes in disability and depression across time was complex. In trying to understand changes in depression, the absolute change in disability may be less important than the relative change and rate of change. The results were discussed in relation to findings from other disease groups, and the implications for the clinical management of depression in Parkinson's disease.

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 1 , February 1988 , pp. 49 - 55
Copyright
Copyright © Cambridge University Press 1988

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References

Beck, A. T. & Beamesderfer, A. (1974). Assessment of depression: the depression inventory. In Psychological Measurements in Psychopharmacology, volume 7 (ed. Pichot, P.), Karger-Basel: Paris.Google Scholar
Bridges, K. W. & Goldberg, D. P. (1984). Psychiatric illness in inpatients with neurological disorders: patient's views on discussion of emotional problems with neurologists. British Medical Journal 289, 656–658.CrossRefGoogle ScholarPubMed
Brown, G. L. & Wilson, W. P (1972). Parkinsonism and depression. Southern Medical Journal 65, 540–545.CrossRefGoogle ScholarPubMed
Cassileth, B. R., Lusk, E. J., Strouse, T. B., Miller, D. S., Brown, L. L., Cross, P. A. & Tenaglia, A. N. (1984). Psychosocial status in chronic illness. A comparative analysis of six diagnostic groups. New England Journal of Medicine 311, 506–511.CrossRefGoogle ScholarPubMed
Celesia, G. G. & Wanamaker, W. M. (1972). Psychiatric disturbances in Parkinson's disease. Diseases of the Nervous System 33, 577–583.Google Scholar
Gotham, A.-M., Brown, R. G. & Marsden, C. D. (1986). Depression in Parkinson's disease: a quantitative and qualitative analysis. Journal of Neurology, Neurosurgery and Psychiatry 49, 381–389.CrossRefGoogle ScholarPubMed
Horns, S. (1974). Some psychological factors in parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 37, 27–31.CrossRefGoogle Scholar
Lieberman, A., Dziatolowski, M., Kupersmith, M, Serby, M., Goodgold, A., Korein, J. & Goldstein, M. (1979). Dementia in Parkinson's disease. Annals of Neurology 6, 355–359.CrossRefGoogle Scholar
Marsh, G. G. & Markham, C. H. (1973). Does Levodopa alter depression and psychopathology in parkinsonism patients? Journal of Neurology, Neurosurgery and Psychiatry 36, 925–935.Google Scholar
Mayeux, R, Stern, Y., Rosen, J. & Leventhal, J. (1981). Depression, intellectual impairment and Parkinson's disease Neurology 31, 645–650.CrossRefGoogle Scholar
Mayeux, R., Williams, J. B. W., Stern, Y. & Cote, L. (1984). Depression and Parkinson's disease. In Advances in Neurology Vol. 40. Parkinson-specific Motor and Mental Disorders, Role of the Pallidum. Pathophysiological, Biochemical and Therapeutic Aspects. (ed. Hassler, R. G. and Christ, J. F.), pp. 241–250. Raven Press: New York.Google Scholar
Mindham, R. H. S. (1970) Psychiatric symptoms in parkinsonism. Journal of Neurology, Neurosurgery and Psychiatry 33, 188–191.Google Scholar
Mindham, R. H. S., Marsden, C. D. & Parkes, J. D. (1976). Psychiatric symptoms during L-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychological Medicine 6, 23–33.Google Scholar
Mindham, R. H. S., Bagshaw, A., James, S. A. & Swannell, A. J. (1981). Factors associated with the appearance of depression in rheumatoid arthritis. Journal of Psychosomatic Research 25, 429–435.Google Scholar
Moos, R. H. & Solomon, G. F. (1964). Personality correlates of the rapidity of progression in rheumatoid arthritis. Annals of Rheumatic Disease 23, 145–151.Google Scholar
Robins, A. H. (1976). Depression in patients with parkinsonism. British Journal of Psychiatry 128, 141–145.CrossRefGoogle ScholarPubMed
Santamaria, J., Tosala, E. & Valles, A. (1986). Parkinson's disease with depression a possible subgroup of patients with idiopathic parkinsonism. Neurology 36, 1130–1133.CrossRefGoogle ScholarPubMed
SPSS-X. (1983). McGraw Hill: New York.Google Scholar
Vogel, H. P. (1982). Symptoms of depression in Parkinson's disease. Pharmacopsychiatrica 15, 192–196.Google Scholar
Warburton, J. W. (1967). Depressive symptoms in parkinsonian patients referred for thalamotomy. Journal of Neurology, Neurosurgery and Psychiatry 30, 368–370.Google Scholar