Trends in Cognitive Sciences
ReviewFeature ReviewThe neurochemistry of music
Introduction
Music is one of a small set of human cultural universals [1], evoking a wide range of emotions, from exhilaration to relaxation, joy to sadness, fear to comfort, and even combinations of these 2, 3, 4. Many people use music to regulate mood and arousal, much as they use caffeine or alcohol 5, 6, 7. Neurosurgeons use it to enhance concentration [8], armies to coordinate movements and increase cooperation [9], workers to improve attention and vigilance [10], and athletes to increase stamina and motivation [11].
The notion that ‘music is medicine’ has roots that extend deep into human history through healing rituals practiced in pre-industrial, tribal-based societies [12]. In contemporary society, music continues to be used to promote health and well-being in clinical settings, such as for pain management, relaxation, psychotherapy, and personal growth. Although much of this clinical use of music is based on ad hoc or unproven methods, an emerging body of literature addresses evidence-based music interventions through peer-reviewed scientific experiments. In this review, we examine the scientific evidence supporting claims that music influences health through neurochemical changes in the following four domains:
- (i)
reward, motivation and pleasure;
- (ii)
stress and arousal;
- (iii)
immunity; and
- (iv)
social affiliation.
These domains parallel, respectively, the known neurochemical systems of
- (i)
dopamine and opioids;
- (ii)
cortisol, corticotrophin-releasing hormone (CRH – see Glossary), adrenocorticotropic hormone (ACTH);
- (iii)
serotonin and the peptide derivatives of proopiomelanocortin (POMC), including alpha-melanocyte stimulating hormone and beta-endorphin; and
- (iv)
oxytocin.
Although the evidence is often weak or indirect and all studies suffer from important limitations (Box 1), the reviewed evidence does provide preliminary support for the claim that neurochemical changes mediate the influence of music on health. Please note that in this article, we differentiate ‘Music Therapy’, a professional discipline and associated practice, from general music interventions.
Section snippets
Reward, motivation, and pleasure
All organisms engage in motivated behaviors geared towards survival [13]. This can be for individual survival, such as seeking out and ingesting food, or survival of the species, such as sexual activity. Reward is a complex construct involving motivational states (e.g., craving or wanting), prediction, goal-directed behavior, reinforcement learning, and hedonic states (Box 2). Is music the same or different than other rewards, including food, sex, and drugs of abuse? Does music have the
Stress and arousal
All organisms seek to maintain homeostasis. Stress can be defined as a neurochemical response to the loss of homeostatic equilibrium, motivating the organism to engage in activities that will restore it (Box 3). Lifestyle choices that reduce stress are thought to be highly protective against diseases [48] and music may be among these 49, 50, 51.
Immunity
Immune responses are broadly categorized as either innate or adaptive. The innate immune system represents the first line of defense against infection and includes cells and proteins that are nonspecific to particular antigens, such as natural killer (NK) cells and phagocytes. The adaptive immune system provides a secondary, antigen-specific response during which cells with a memory for specific pathogens are created (e.g., T cells; [89]).
Stress and aging have detrimental effects on both immune
Social affiliation
An emerging body of evidence indicates that social factors play an important role in human health outcomes [109]. Synchronized activities, such as music, dance, and marching, have long been known to foster feelings of social connection, specifically interpersonal trust and bonding 9, 110, 111 (see also [112], for a review of dance as therapy for Parkinson's patients). Many human and animal activities are rhythmic, including walking, talking, clapping our hands, dancing, sexual activity, and
Concluding remarks
Claims about the healing power of music are found in many pre-industrial societies and in ancient Greece. Over the past three decades, modern experimental methods have been brought to bear on the question of whether the effects are genuine and whether they are attributable to music per se as opposed to ancillary or confounding factors. A great deal has been discovered about the neuroanatomical basis for music [121], whereas not much is known about its neurochemical basis. Studies of the
Acknowledgements
This work was supported by grants from the Natural Sciences and Engineering Research Council (NSERC) and the Social Sciences and Humanities Research Council (SSHRC) to D.L. We gratefully acknowledge editorial assistance from Stefan Koelsch and Gunter Kreutz; research assistance from Dale Boyle, Holly Boyle, Dawna Coleman, Sara Florence, Ladan Mahabadi, and Jordana Saks; and Salgood Sam for illustrating Figure 1.
Glossary
- Adrenocorticotropic hormone (ACTH)
- a hormone synthesized by the anterior pituitary, which, in turn, stimulates the adrenal cortex to release corticosteroid hormones, including cortisol.
- Anterior cingulate cortex (ACC)
- the frontal part of the cingulate cortex; regulates autonomic functions (blood pressure and heart rate), as well as attention, reward anticipation, decision-making, empathy, and emotion.
- ß-endorphin
- an endogenous opioid peptide neurotransmitter found in the central and peripheral
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