Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine
Under a Creative Commons license
open access
Graphical abstract
Keywords
Sleep
Circadian
Plasticity
Depression
Rapid-acting antidepressant
Slow-wave sleep
Abbreviations
AMPAR
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
BDNF
brain-derived neurotrophic factor
BMAL1
brain and muscle ARNT-like protein 1
CREB
cAMP related element binding protein
CLOCK
Circadian Locomotor Output Cycles Kaput
CRY
cryptochrome
EEG
electroencephalography
ENCORE-D
encoding consolidation and renormalization in depression
ERK
extracellular-signal regulated kinase
GABA
gamma-aminobutyric acid
GSK3β
glycogen synthase kinase 3β
HNK
hydroxynorketamine
LTP
long-term potentiation
mPFC
medial prefrontal cortex
mRNA
messenger ribonucleic acid
mTOR
mammalian target of rapamycin
NMDAR
N-methyl-D-aspartate receptor
per
period
NREM
non-rapid-eye movement sleep
REM
rapid-eye movement sleep
SD
sleep deprivation
SHY
synaptic homeostasis hypothesis
RORα
retinal orphan receptor α
SCN
suprachiasmatic nucleus
SWA
slow wave activity
SWS
slow wave sleep;
TrkB
tropomyosin related receptor B.
Cited by (0)
- 1
Equal contribution.
© 2020 The Author(s). Published by Elsevier Inc.