Original articleEvaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans
Section snippets
Patients
One hundred twenty-nine eyes from 72 glaucoma patients followed up from March 2003 through August 2009 were included. At least 4 serial RNFL measurements were obtained from each eye with both the fast and regular RNFL scans at the same visit, and with the first and the last measurements separated by at least 2.9 years. All subjects underwent a full ophthalmic examination, including visual acuity, refraction, intraocular pressure measurement with Goldmann tonometry, gonioscopy, and fundus
Results
A total of 1373 fast RNFL scans with the corresponding 1373 regular RNFL scans and 1236 visual field tests collected from 129 eyes (72 glaucoma patients) were analyzed. The follow-up duration ranged between 2.9 to 6.1 years with a median follow-up of 4 months. The average number of OCT scans and visual field tests for each eye was 10.6 and 9.6, respectively. The average RNFL thicknesses measured with the fast and regular RNFL scans were 76.8±19.0 μm and 75.5±18.6 μm at baseline and 73.8±19.1 μm
Discussion
Despite the fact that both the fast and the regular RNFL measurements were collected in the same follow-up visits, the agreement for detection of progressive RNFL thickness reduction between the 2 scan protocols surprisingly was only fair to moderate, and the regular RNFL scan seems to be less specific for detecting clock hour RNFL progression. A significant proportion of eyes demonstrated increasing clock hour RNFL thicknesses with age when the measurements were obtained with the regular scan.
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Manuscript no. 2010-347.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
Christopher Kai Shun Leung - Financial support - Carl Zeiss Meditec.
Robert Neal Weinreb - Consultant and Financial support - Carl Zeiss Meditec.