Original ArticleChitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine
Section snippets
Materials
The drug tacrine (9-amino-1,2,3,4-tetrahydroacridine) was purchased from Sigma (St. Louis, Missouri). Linseed oil was purchased from National Chemicals (Vadodara, India). Chitosan was a gift from Central Marine Fisheries Research Institute (Cochin, India). All other materials and reagents used in the study were analytical/high-performance liquid chromatography (HPLC) grade and used as purchased.
Preparation of chitosan nanoparticles
The chitosan nanoparticles containing the drug tacrine were prepared by the method of spontaneous
Nanoparticles
Chitosan nanoparticles of the drug tacrine with different drug-to-polymer ratios (1:1, 1:1.5, 1:2, 1:2.5, and 1:3) were prepared by spontaneous emulsification. Table 1 shows the process yield, percentage drug loading, and particle size of chitosan nanoparticles. Yields of production ranged between 77.50% ± 3.17% and 83.33 ± 1.46% depending on the drug-to-polymer ratio used. The nanoparticles prepared using a drug-to-polymer ratio of 1:1 showed the highest value. The drug-loading capacity
Preparation of chitosan nanoparticles
Chitosan nanoparticles of the drug tacrine with different drug-to-polymer ratios (1:1, 1:1.5, 1:2, 1:2.5, and 1:3) were prepared by spontaneous emulsification. Chitosan has many advantages for developing nanoparticles, including the ability to control the release of active agents and avoidance of the use of hazardous organic solvents while fabricating particles because of its solubility in aqueous acidic solution; it is a linear polyamine containing a number of free amine groups that are
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No conflict of interest was reported by the authors of this article.