Elsevier

Materials Science and Engineering: C

Volume 83, 1 February 2018, Pages 218-232
Materials Science and Engineering: C

Review
Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives

https://doi.org/10.1016/j.msec.2017.10.004Get rights and content

Highlights

  • The polyester based biomaterials have demonstrated high potential for drug delivery.

  • The major types of polyesters used in the biomedical fields have been summarized.

  • The state-of-the-art of polyester micelles for drug delivery and cancer theranostics has been reviewed.

  • This review has summarized current clinical achievements of polyester micelles and recent progresses of multi-functional polyester micelles for tumor molecular imaging and therapeutic applications.

Abstract

The development of tumor-targeting nanocarriers is critical important for effective treatment. The synthetic polyesters have demonstrated high potential for developing nanocarriers for cancer theranostics. Especially, the biocompatible and biodegradable polyester micelles have held great promise for cancer therapy and diagnosis, while some candidates have been translated into clinical applications or under clinical trial. In this review, we have provided the state-of-the-art of polyester micelles for drug delivery and cancer theranostics. In addition, we have summarized several major types of polyesters used in the biomedical fields, the current clinical achievements of polyester micelles and recent progresses of multi-functional polyester micelles for tumor molecular imaging and therapeutic applications.

Keywords

Polyester
Micelle
Cancer therapy
Drug delivery systems
Theranostics

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