Molecular Cell
Volume 37, Issue 4, 26 February 2010, Pages 492-502
ArticleHydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
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open access
Graphical Abstract
Highlights
► RAD51 promotes replication fork restart after short hydroxyurea (HU) blocks ► RAD51-mediated fork restart does not create homologous recombination (HR) products ► Long HU blocks lead to fork collapse; replication is restarted by new origin firing ► Collapsed replication forks are repaired by classical RAD51-dependent HR
DNA
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Present address: Departments of Radiation Oncology and Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109-5637, USA
Copyright © 2010 Elsevier Inc.