Review
Vitamin D status, receptor gene polymorphisms, and supplementation on tuberculosis: A systematic review of case-control studies and randomized controlled trials*,

https://doi.org/10.1016/j.jcte.2014.08.001Get rights and content
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open access

Highlights

  • Lower serum 25-hydroxyvitamin D increases susceptibility to tuberculosis.

  • BsmI and FokI VDR gene polymorphisms may confer increased risk of acquiring tuberculosis.

  • Vitamin D supplementation reduces tuberculosis incidence and increases recovery from tuberculosis.

Abstract

Objective

To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB).

Methods

We conducted a systematic review of published studies pertaining to case–control and randomized-control trials from 2002 to 2014 using the PubMed database.

Results and conclusion

Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.

Keywords

Vitamin D
Vitamin D receptor
Polymorphism
Tuberculosis
Supplementation
Clinical trials

Abbreviations

TB
tuberculosis
25(OH)D
25-hydroxyvitamin D
1α,25(OH)2D
1α,25-dihydroxyvitamin D
VDR
vitamin D receptor
WT homo
wild-type homozygous
HT
heterozygous
VR
variant recessive
TST
Tuberculin Skin Test

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*

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Conflicts of interest: None declared.