Letter to the editorFilaggrin mutations increase the risk for persistent dry skin and eczema independent of sensitization
References (8)
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Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
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(2006) Fleshing out filaggrin phenotypes
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Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis
J Invest Dermatol
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Atopic dermatitis and concomitant disease patterns in children up to two years of age
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Cited by (26)
Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis
2018, Journal of Dermatological ScienceCitation Excerpt :Although FLG is one of many barrier proteins [29], it is likely to be involved in the functional integrity of the epidermal barrier [14]. A loss-of-function mutation of FLG causes dry skin and is critically involved in the pathogenesis of atopic dermatitis and experimental animal disease phenotypes [13,15,34]. Moreover, the topical application of apigenin, a phytochemical AHR activator, improves epidermal barrier homeostasis by upregulating FLG expression in normal murine skin [17].
IgE sensitization in relation to preschool eczema and filaggrin mutation
2017, Journal of Allergy and Clinical ImmunologyCitation Excerpt :All samples were analyzed in accordance with the instructions of the manufacturer at the Department of Clinical Immunology, Karolinska University Hospital Solna, Stockholm, Sweden. In addition, genotyping for the FLG mutations common in Scandinavia was done among children who provided blood at 8 years of age.22 Genotyping was performed with TaqMan allelic discrimination for R501X and R2447X on the ABI Prism 7500 detection system in accordance with the manufacturer's protocol (Applied Biosystems, Foster City, Calif) and matrix-assisted laser desorption/ionization time-of-flight spectrometry (Sequenom GmbH, Hamburg, Germany) for 2282del4.
Pathophysiology of atopic dermatitis
2017, Annales de Dermatologie et de VenereologiePersistence of atopic dermatitis (AD): A systematic review and meta-analysis
2016, Journal of the American Academy of DermatologyCitation Excerpt :After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies3-48 were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender,6,23,28,31,44,45,48 6 for allergen sensitization,6,17,23,36,40,45 and 3 for baseline AD severity17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1.
New pathogenic and therapeutic paradigms in atopic dermatitis
2015, CytokineCitation Excerpt :It is believed that loss-of-function mutations in FLG may change the shape of epidermal corneocytes, therefore disrupting their function and also altering the organization of extracellular lamellar bodies [30,33]. Patients with FLG mutations are not only predisposed to the formation of AD, but were also found to have early onset of recalcitrant AD, and disease that is more likely to be associated with asthma, food allergy, and cutaneous infections [37–39]. Recent studies in mice have stressed the interaction of FLG with other genes.
Anatomical patterns of dermatitis in adult filaggrin mutation carriers
2015, Journal of the American Academy of DermatologyCitation Excerpt :FLG genotyping is currently gaining more attention as a diagnostic tool to understand the etiology of disease when treating patients in dermatologic clinics. Palmar hyperlinearity37 and dry skin38 are currently used as indications of FLG haploinsufficiency. In our study the OR of foot dermatitis, among participants with AD, was increased more than 3-fold when participants also carried FLG mutations.
This study was funded by the Swedish Asthma and Allergy Association, the Welander-Finsen Foundation, and the Swedish Research Council. Financial support was also provided through regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet.
Disclosure of potential conflict of interest: C.-F. Wahlgren received research support from the Swedish Asthma and Allergy Association, the Welander-Finsen Foundation, and the Stockholm County Council (ALF). The rest of the authors declare that they have no relevant conflicts of interest.
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Shared first authorship.