Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity
Graphical abstract
Section snippets
Psoriasis
Psoriasis, a chronic non-infectious disease, has been reported worldwide. Because registration of psoriasis cases is not compulsory, there are few studies about the onset of psoriasis and these studies are not very reliable [1]. It is roughly estimated that 3% of people worldwide have psoriasis [2,3]. Psoriasis could be divided into five types according to its pathological manifestation, and the most common type being plaque psoriasis, which causes pain and itching in affected patients. In
Materials
Cel were obtained from Chengdu Pufei De Biotech Co., Ltd. (Chengdu, China). Span 20, Span 60, and cholesterol were all purchased from Aladdin Industrial Corporation (Shanghai, China). Carbopol 974 powder was obtained from Chineway (Shanghai, China). Imiquimod cream (IMQ; 5%) as Aldara and tacrolimus ointment (0.1%) as Protopic were purchased from Kangaiduo Drug Store (Guangzhou, China). Paraformaldehyde (4%) was purchased from Phygene (Fuzhou, China). High-performance liquid chromatography
Characterization of Cel Nio
After preliminary screening of the formulation (data not shown), a Span 20, Span 60, and cholesterol ratio of 3:1:1 (w/w/w), hydration time of 30 min, and sonication time of 2 min were selected. This optimized formulation had a smaller particle size and higher drug loading ability. Therefore, this formulation was selected to be used in the subsequent experiment. A graph of size distribution is shown in Fig. 1(A). The particle size of Cel Nio was approximately 147.4 nm ± 5.6 nm with a PDI of
Conclusion
In this study, Nio hydrogels loaded with Cel were developed as an effective treatment of psoriasis-like mouse model induced by IMQ. Cel Nio had an average particle size of approximately147 nm with small PDI. Encapsulation of Cel into Nio increased the water-solubility and permeation of Cel in the skin, significantly improving its anti-psoriasis activity in the mice model. Thus, the results indicated the potential application of Cel Nio hydrogel in psoriasis therapy.
Acknowledgement
This study was financially supported by the Macao Science and Technology Development Fund (0013/2018/A1).
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