Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin
Graphical abstract
3,4-Dihydropyrimidinones of curcumin were synthesized in excellent yield by multi-component one-pot condensation of curcumin, substituted aromatic aldehydes and urea/thiourea under solvent free conditions using SnCl2·2H2O catalyst.
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Acknowledgments
The authors are indebted to Madhya Pradesh Council of Science and Technology, Bhopal for financial support (Grant No. 4468/CST/R&D/2010), the Director, Defense Research & Development Establishment, Jhansi Road, Gwalior-474 002 (M.P.), for carrying out biological activity of the synthesized compounds.
References and notes (29)
- et al.
Tetrahedron
(2008) - et al.
Mutat. Res.
(1993) - et al.
Eur. J. Med. Chem.
(2009) - et al.
Bioorg. Med. Chem.
(2011) - et al.
Bioorg. Med. Chem.
(2008) - et al.
Mutat. Res.
(2002) - et al.
J. Pharma. Sci.
(2011) - et al.
J. Pharma. Sci.
(2011) - et al.
Eur. J. Med. Chem.
(2007) - et al.
J. Biol. Chem.
(2005)
Bioorg. Med. Chem.
(2006)
Tetrahedron Lett.
(2007)
Bioorg. Med. Chem. Lett.
(2011)
Phytochem. Anal.
(2009)
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