Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities
Graphical abstract
The asymmetric total synthesis of the strongly cytotoxic phenanthroindolizidine alkaloid 3 was achieved. Using the same route, various derivatives were also synthesized. Cytotoxicity of those synthetic compounds and the in vivo antitumor efficacy of selected compounds were evaluated.
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Acknowledgments
The authors thank Miyuki Uchida and Fukiko Nishisaka for their excellent technical assistance.
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