Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1822, Issue 8, August 2012, Pages 1189-1197
Impaired protein quality control system underlies mitochondrial dysfunction in skeletal muscle of streptozotocin-induced diabetic rats
Under an Elsevier user license
open archive
Graphical abstract
Highlights
► After 4 months of STZ administration gastrocnemius IMF mitochondria functionality decreased. ► Increased mitochondria carbonylation levels were paralleled by decreased OXPHOS activity. ► Decreased mitochondria proteolysis was related with increased protein oxidation. ► AAA proteases activity and expression decreased in diabetic animals.
Abbreviations
BN-PAGE
blue native polyacrylamide gel electrophoresis
Anti-DNP
anti-2,4-dinitrophenylhydrazone
OXPHOS
oxidative phosphorylation
IMF
intermyofibrillar mitochondria
STZ
streptozotocin
T1DM
type 1 diabetes mellitus
Keywords
Intermyofibrillar mitochondria
Mitochondrial proteolysis
Protein quality control
Gastrocnemius
Type 1 diabetes mellitus
Cited by (0)
Copyright © 2012 Elsevier B.V. All rights reserved.