Molecular Nutrition

Molecular Nutrition

Vitamins
2020, Pages 301-322
Molecular Nutrition

Chapter 16 - New properties of vitamin B6 or pyridoxine in experimental oxidative stress in the brain

https://doi.org/10.1016/B978-0-12-811907-5.00017-8Get rights and content

Abstract

Pyridoxine possesses antioxidative as well as cell-regenerative and proproliferative activities. Numerous publications explain the abovementioned effect based on pyridoxine binding with the steroid hormone receptors, which belong to a superfamily of transcription factors that regulate physiological processes such as growth, development, reproduction, and behavior. Based on our investigations we proposed and proved that B6 proproliferative abilities are mediated via the inhibition of xanthine oxidoreductase enzyme (XOR; EC 1.17.3.2), responsible for the last steps of purine catabolism. One of the products of XOR is hydrogen peroxide, which serves as the source for the generation of free radicals. Consequently, the inhibition of XOR will trigger regenerative and proliferative functions of the cells and will prevent the generation of free radicals. This proposed idea was proved experimentally in vivo and in vitro.

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