The S100 family of EF-hand calcium-binding proteins: functions and pathology

doi:10.1016/S0968-0004(96)80167-8

Trends in Biochemical Sciences

Volume 21, Issue 4, April 1996, Pages 134-140

https://doi.org/10.1016/S0968-0004(96)80167-8 Get rights and content

Calcium ions as second messengers control many biological processes, at least in part, via interaction with a large number of Ca²⁺-binding proteins. One class of these proteins shares a common Ca²⁺-binding motif, the EF-hand. Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.

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¹: B. W. Schäfer and C. W. Heizmann are at theDivision of Clinical Chemistry, Department of Pediatrics, University of Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

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Trends in Biochemical Sciences

The S100 family of EF-hand calcium-binding proteins: functions and pathology

Cell

Trends Biochem. Sci.

J. Invest. Dematol.

Genomics

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Brain Res. Bull.

Prog. Neurobiol.

J. Biol. Chem.

Cell Calcium

Trends Biochem. Sci.

Biochem. Biophys. Res. Commun.

CRC Crit. Rev. Biochem.