Electrochemical and peroxidase oxidation study of N′-Hydroxyguanidine derivatives as NO donors

doi:10.1016/S0960-894X(02)00185-3

Bioorganic & Medicinal Chemistry Letters

Volume 12, Issue 11, 3 June 2002, Pages 1507-1510

https://doi.org/10.1016/S0960-894X(02)00185-3 Get rights and content

Abstract

The electrochemical properties of a series of N-substituted-N′-hydroxyguanidines were studied. Two oxidation potentials of each compound were obtained by cyclic voltammetry. The E_ox1 values were from 0.51 to 0.62 V, while the E_ox2 values were from 1.14 to 1.81 V in acetonitrile solution. Next, their enzymatic controlled NO release abilities were evaluated. All N′-hydroxyguanidines exhibited efficient NO release abilities under the oxidation by horseradish peroxidase in the presence of H₂O₂.

Oxidation potentials of a series of N-substituted-N′-hydroxyguanidines and their NO release abilities under the oxidation of horseradish peroxidase/H₂O₂ were evaluated.

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Acknowledgements

Financial support from the National Institutes of Health (GM 54074) is gratefully acknowledged.

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Electrochemical and peroxidase oxidation study of N′-Hydroxyguanidine derivatives as NO donors

Abstract

Section snippets

Acknowledgements

Biochim. Biophys. Acta

Structure

J. Biochem. Pharmacol.

Biochem. Pharm.

Bioorg. Med. Chem. Lett.

Biochem. Pharm.

R. Acad. Sci. II

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

Tetrahedron Lett.

Anal. Biochem.

Biochimie

Bioorg. Med. Chem. Lett.

Bioorg. Med. Chem. Lett.

Biochem. J.

FASEB J.

Biochemistry (Moscow)