Lobule-dependent zonal measurement (LZM) method for the determination of cell proliferation in the liver
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Cited by (16)
Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance
2019, ToxicologyCitation Excerpt :To study effects on hepatocyte RDS, slides were dewaxed and processed for BrdU immunocytochemistry. Positively stained cells were characterised by a red reaction product over the nuclei and were counted (at least 1000 cells per zone) in zones 1 (periportal), 2 (midzonal) and 3 (centrilobular) areas of the liver lobule (Bahnemann and Mellert, 1997) using an image analysis system (Quantimed 500, Zeiss, Germany). To study effects of metazachlor on nuclear translocation of CAR and hepatic mRNA levels, groups of female Wistar rats (n = 6 per group) were fed diets containing 0, 500 ppm NaPB and 8000 ppm metazachlor periods of 3 and 7 days, whereas in another study groups of male and female Wistar rats (n = 10 per group) were fed diets containing 0 and 8000 ppm metazachlor for 14 days and hepatic enzyme activities and CYP mRNA levels were determined as detailed below.
Standardized assessment of cell proliferation: The approach of the RITA-CEPA working group
2005, Experimental and Toxicologic PathologyInvestigations on cell proliferation in B6C3F<inf>1</inf> mouse liver by diethanolamine
2004, Food and Chemical ToxicologyCitation Excerpt :In each of the measurement fields, 80–120 hepatocytes were counted. By means of this procedure, a total of more than 1000 cells per zone (=more than 3000 cells per animal) were evaluated (Bahnemann and Mellert, 1997; Goldsworthy et al., 1991, 1993). Body weights and food consumption were analysed by comparison of the dose group with the control group using the Welch t-test (two-sided) for the hypothesis of equal means (Welch, 1947).
Tumor induction in mouse liver: Di-isononyl phthalate acts via peroxisome proliferation
2002, Regulatory Toxicology and PharmacologyInvestigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
2023, Toxicologic Pathology