Peripheral nerve regeneration, repair, and grafting
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Electrophysiological, functional and histopathological assessments of high dose melatonin on regeneration after blunt sciatic nerve injury
2020, Journal of Clinical NeuroscienceSilicone-based simulation models for peripheral nerve microsurgery
2019, Journal of Plastic, Reconstructive and Aesthetic SurgeryCitation Excerpt :Although technological aids such as operating microscopes and microsurgical suture materials provided significant improvements in peripheral nerve microsurgery, the repair of these nerves still remains as a challenge due to the complex nature of these structures.41,42 Treatment plan necessitates an accurate classification of the nerve injury43 and the most severe type of these nerve injuries is the fifth-degree (Seddon's neurotmesis)44,45 injuries, in which all of the sub-structures of the peripheral nerve (i.e., endoneurium, the fascicles, Schwann cells, axons, and the epineurium) are completely ruptured. Precise alignment at the fascicular level with shorter operation, dissection, and anesthetic times are also crucial for the post-operative functional repair of the nerves.
Nerve Repair
2016, Hand and Upper Extremity Rehabilitation: A Practical GuideRetrograde response in axotomized motoneurons: Nitric oxide as a key player in triggering reversion toward a dedifferentiated phenotype
2014, NeuroscienceCitation Excerpt :Under these conditions, the accumulation of fibrotic scar tissue at the site of injury presents a physical obstacle for regenerating axons. Likewise, complete disruption of the connective sheaths in the distal stump of the injured nerve involves the loss of a structural and molecular guide that otherwise would instruct and support axonal regeneration (Dagum, 1998; Nguyen et al., 2002). Besides the regenerative and degenerative responses initiated locally at the site of injury in severed axons, axotomy of peripheral fibers leads to a characteristic retrograde reaction that proximally affects cell bodies, dendrites, and surrounding environment of the lesioned neurons (Lieberman, 1971; Bishop, 1982; Kreutzberg, 1995; Hanz and Fainzilber, 2006).
Pudendal neuralgia
2014, Obstetrics and Gynecology Clinics of North America