Computed tomography features in malignant pleural mesothelioma and other commonly seen pleural diseases
Introduction
Malignant pleural mesothelioma (MPM) is an uncommon neoplasm with a poor prognosis [1], [2]. The definitive diagnosis of MPM depends on histopathologic evaluation of biopsy specimens [2], [3]. In recent years, computed tomography (CT) of the chest has been used for diagnosing, staging and follow-up examinations of patients with MPM [4], [5], [6]. The largest series in which the CT features of mesothelioma were described comprised 84 patients from Turkey [7]. That study and subsequent reports have shown that the CT features of MPM are characteristic but not pathognomonic [7], [8], [9]. A variety of benign and malignant diseases may cause pleural abnormalities that resemble MPM. The most common causes are metastatic carcinoma, tuberculous pleurisy (TP), empyema, and asbestos-related advanced pleural abnormalities [7], [8], [10]. The pleural responses to these diseases may manifest radiologically as an effusion, pleural thickening, or calcification [8], [10]. The characteristic CT appearances of these pleural diseases have been described [10], [11], [12].
In only one study, the value of CT in the differential diagnosis of pleural diseases and the overlap between different benign and malignant diseases was analyzed [8]. The conclusion was that most cases of MPM could not be differentiated from metastatic pleural disease (MPD) by CT scan, and that in the presence of pleural thickening, the most useful features for differentiation of malignancy in pleural diseases was the presence of a pleural rind, pleural nodularity, thickening greater than 1 cm, and mediastinal pleural involvement [8]. However, this study had a limited number of patients. The aim of our study was to investigate the CT features of MPM, and other malignant and benign pleural diseases in a large patient cohort.
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Patients
Between May 1989 and October 1998, 215 patients with malignant or benign pleural disease were included in the study retrospectively. All MPM cases diagnosed in this period were included. All patients presented with either MPD, TP, empyema or asbestos-related advanced benign pleural disease (ARBPD). There were 99 patients with MPM, 39 with MPD, 32 with TP, 26 with empyema and 19 with ARBPD. Among the 39 patients with MPD, 21 had bronchial carcinoma, 2 lymphoma, 6 mammary carcinoma, 9 carcinoma
Radiological findings
The CT findings; effusion, effusion size, extension and configuration of lesions, are listed in Table 1.
Although a pleural effusion was present in most patients with MPM, MPD, TP and in all cases with empyema, it was detected in only 16% of ARBPD cases. Minimal and moderate sized effusion was the rule in benign pleural disease.
In the majority of patients with MPM, the extension of tumor on pleural surface was in the form of a pleural rind (Fig. 1). In patients with MPD, TP, ARBPD or empyema,
Discussion
Malignant mesothelioma is an unusual tumor with an incidence of 1–2.2/million population [1]. However, in some rural regions of Turkey, malignant mesothelioma is endemic due to environmental exposure to asbestos [1]. Although the clinical features of MPM are well known, a definite diagnosis of this disease depends on extensive histopathological examination of biopsy samples obtained by invasive procedures [3], [13].
The radiologic evaluation of MPM was revolutionised with the introduction of CT
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