Spectrochimica Acta Part B: Atomic Spectroscopy
Ion mobility spectrometer for online monitoring of trace compounds☆
Introduction
Ion mobility spectrometry (IMS) emerged as an analytical technique in 1970s [1], but its development followed an unconventional and uneven pattern. The first enthusiasm for the simplicity of the instrument and the astonishing detection limits for IMS was followed by a broad rejection of the method, because at that time the principles of ion molecule chemistry and ion behavior at atmospheric pressure were poorly understood. During the 1990s, great advances in technology, design and commercialization took place. IMS evolved into an inexpensive and powerful technique for sensitive detection of many trace compounds such as chemical warfare agents [2], drugs of abuse [3], [4], [5], explosives [6], [7] and atmospheric pollutants [8], [9], [10]. Inorganic substances including alkali salts [11] and other metal salts (Al, Mn, Pb, La, Sr, etc.) [12], [13] can also be detected and separated. The advantages of this technique are high sensitivity, low cost, analytical flexibility, and real time monitoring capability. IMS also compares favorably to different organic molecular-based analytical techniques with respect to size, weight, power consumption and information density.
Previously, IMS was consigned to only a few selected security and military applications, and research was performed only in a handful of government, industry and university laboratories. The intent of this paper is to provide the reader an overview of the basic principle, instrumentation and application of IMS, as well as some of the limitations and future possibilities of using this method in analytical chemistry.
Section snippets
Principles of ion mobility spectrometry
The term ion mobility spectrometry refers to the method of characterizing chemical substances using gas-phase mobilities of ions in weak electric fields. It works in a similar way to a time-of-flight mass spectrometer (TOF-MS), the major difference is that TOF-MS requires a vacuum. A typical ion mobility spectrometer is comprised of an ionization source associated with an ion reaction chamber, an ion drift chamber, an ion/molecule injection shutter (e.g. Bradbury–Nielsen-shutter) placed between
Chemical warfare agents, explosives, drugs and explosive-related compounds
Explosives detection has been one of the principle reasons (along with chemical warfare agent and drug detection) for the development of IMS technology [16], [17], [18], [19], [20], [21], [22]. The combination of sensitivity and ruggedness provides a good solution to the complex issue of explosives counter-terrorism. The IMS systems designed for this application were developed for the detection of explosive particles, rather than vapors released from explosive materials, due to the extremely
Ion sources for IMS
Most of the ion mobility spectrometers use radioactive sources as an ionization source such as 63Ni [38], [39], [40], [41], which is favored due to its simplicity, stability and convenience. This source, however, has serious deficiencies with a limited linear range, inflexible selectivity and the regulatory requirements associated with radioactive materials. In recent years non-radioactive ion sources have been applied more frequently. UV lamps [42], [43], [44] (ionization energy as 10.6 eV),
Conclusion and outlook
Ion mobility spectrometry has become the one of the most successful and widely used technology for the detection of trace levels of compounds in both the laboratory and the field. Micromachining of the instrument promises cost, size and power reductions. The extension of IMS to high molecular weight compounds employing electrospray or MALDI source holds much promise. The development of coupling MS to IMS is crucial to understand complex chemistry occurring in the ionization source and drift
References (72)
- et al.
Atmospheric pressure chemical ionization of alkanes, alkenes, and cycloalkanes
J. Am. Soc. Mass Spectrom.
(1994) - et al.
Determination of bromine in air by ion mobility spectrometry
Anal. Chim. Acta.
(1991) - et al.
Differentiating between large isomers and derivation of structural information by ion mobility spectrometry/mass spectrometry techniques
Int. J. Mass Spectrom. Ion Processes
(1988) - et al.
Rapid mutivariate curve resolution applied to identification of explosives by ion mobility spectrometry
Anal. Chim. Acta
(2001) - et al.
Quantitative calibration of vapor levels of TNT, RDX, and PETN using a diffusion generator with gravimetry and ion mobility spectrometry
Talanta
(1997) - et al.
A critical review of ion mobility spectrometry for the detection of explosives and explosive related compounds
Talanta
(2001) - et al.
Detection of alcohols using UV-ion mobility spectrometers
Anal. Chim. Acta
(2001) - et al.
Hand-held ion mobility spectrometers
Trend Anal. Chem.
(1994) - et al.
Ion mobility spectrometry as flow-injection detector and continuous flow monitor for aniline in hexane and water
Talanta
(1992) - et al.
Determination and identification of pesticides from liquid matrices using ion mobility spectrometry
Anal. Chim. Acta
(2001)
Rapid on-site determination of chlorobenzene in water samples using ion mobility spectrometry
Anal. Chim. Acta
A new method of separation of multi-atomic ions by mobility at atmospheric pressure using a high-frequency amplitude-asymmetric strong electric field
Int. J. Mass Spectrom. Ion Proc.
Separation of protein conformers using electrospray-high field asymmetric waveform ion mobility spectrometry-mass spectrometry
Int. J. Mass Spectrom.
Conformer selection of protein ions by ion mobility in a triple quadrupole mass spectrometer
J. Am. Soc. Mass Spectrom.
A hybrid double-focusing mass spectrometer-high-pressure drift reaction cell to study thermal energy reactions of mass-selected ions
J. Am. Soc. Mass. Spectrom.
Multidimensional separations of complex peptide mixtures: a combined high-performance liquid chromatography/ion mobility/time-of-flight mass spectrometry approach
Int. J. Mass Spectrom.
A novel micromachined high-field asymmetric waveform-ion mobility spectrometer
Sens. Act. B-Chem.
A MEMS radio-frequency ion mobility spectrometer for chemical vapor detection
Sens Act. A-Phys.
Laser desorption–ionization of polycyclic aromatic hydrocarbons from glass surfaces with ion mobility spectrometry analysis
Anal. Chim. Acta
Plasma chromatograph—a new dimension for gas chromatography and mass spectrometry
J. Chromatogr. Sci.
Characterization of benzodiazepine drugs by ion mobility spectrometry
Anal. Chem.
Portable instrumentation: new weapons in the war against drugs and terrorism
Proc. SPIE-Int. Soc. Opt. Eng.
Skin-sniffing/ion mobility spectrometric analysis: a potential screening method in clinical toxicology
J. Clin. Lab. Anal.
Monitoring of airborne organic vapors using ion mobility spectrometry
Int. J. Environ. Anal. Chem.
Ion mobility spectrometry of alkali salts
Int. J. Ion Mobility Spectrom.
Detection of Metal Ion and Ion Complexes by Electrospray Ionization—Ion Mobility Spectrometry
Detection of explosives using laser desorption in ion mobility spectrometry/mass spectrometry
Appl. Spectrosc.
Recent advances in ion mobility spectrometry for explosives vapor detection
J. Test. Eval.
Application of ion mobility spectrometry to the identification of trace levels of explosives in the presence of complex matrices
Rapid Commun. Mass Spectrom.
Detection of volatile vapors emitted from explosives with a handheld ion mobility spectrometer
Field Anal. Chem. Tech.
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2017, TrAC - Trends in Analytical ChemistryCitation Excerpt :A DMS device separates ions based on the difference of their mobility in a high electric field to a low electric field. An asymmetric alternating radio frequency (RF) voltage is applied between two planar or cylindrical electrodes separated by a gap of a few mm or less (Fig. 1a) [16a,26]. The asymmetric waveform is designed such that the low field portion of a given phase has a longer duration than the high field portion to ensure that the product of the amplitude and pulse duration are the same in both the high and low fields (Fig. 2a) [18].
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2015, Science of the Total EnvironmentCitation Excerpt :High resolution MS (HRMS) coupled to GC for PAE determination from sewage sludge (Berset and Etter-Holzer, 2001), soil (Vikelsǿe et al., 1999) allows to discriminate PAEs and their degradation products with a high selectivity due to accurate masses, but do not offer any advantage for routine PAE analysis because it presents lower sensitivity and dynamic range than low resolution classical MS (Segura et al., 2012). PAEs in environmental matrices can also be characterized with high sensitivity by ion mobility spectrometry (IMS), an analytical technique emerged in 1970 (Li et al., 2002). This direct monitoring do not necessitate separation technique before, is very fast (several minutes) and lower cost.
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This paper is published in the special issue of Spectrochimica Acta Part B dedicated to the 50th anniversary of the ISAS.