The nitric oxide hypothesis of brain aging
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The role of arginase in aging: A systematic review
2019, Experimental GerontologyCitation Excerpt :Neurological diseases, particularly neurodegenerative diseases such as Alzheimer's disease (AD), are a major problem of public health in elderly people (Qiu et al., 2007). Arginase activity is critical for the synthesis of polyamines, NO, agmatine and L-ornithine (as precursor of glutamate and γ-aminobutyric acid), which play a crucial role in normal brain cell functioning and neurotransmission (Morris Jr, 2016; Gupta et al., 2012; Minois et al., 2011; McCann, 1997). As a time-dependent decrease in Arg1 expression was found in cultured neurons (Cai et al., 2002), age-related changes in arginase activity could alter central nervous system (CNS) functions by restricting L-arginine-derived biomolecules production or promoting oxidative stress or apoptosis.
Novel drug delivery system for photoinduced nitric oxide (NO) delivery
2015, Inorganic Chemistry CommunicationsAgeing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats
2012, NeuroscienceCitation Excerpt :However, it can be neurotoxic when present in excessive amount due to its properties as a free radical (Calabrese et al., 2007). It has, therefore, been proposed that NO is critically involved in the ageing process, the so-called NO hypothesis of ageing (McCann, 1997; McCann et al., 1998, 2005), as well as the neurodegenerative process in Alzheimer’s disease (Law et al., 2001; Malinski, 2007). Previous research has demonstrated altered NOS activity and expression during ageing in memory-related brain structures and the correlations with age-related cognitive impairments (Sugaya et al., 1996; Law et al., 2000, 2002; Necchi et al., 2002; Liu et al., 2003a,b, 2004a,b, 2005, 2009b).
Neuromeric Distribution of Nicotinamide Adenine Dinucleotide Phosphate-Diaphorase Activity in the Adult Lamprey Brain
2022, Frontiers in NeuroanatomyModulation of the lifespan of: C. elegans by the controlled release of nitric oxide
2020, Chemical ScienceMelatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?
2020, Turkish Journal of Medical Sciences