Elsevier

Neuroscience Letters

Volume 317, Issue 2, 11 January 2002, Pages 111-113
Neuroscience Letters

Apolipoprotein E gene polymorphisms in patients with migraine

https://doi.org/10.1016/S0304-3940(01)02432-6Get rights and content

Abstract

To investigate the role of apolipoprotein E (APOE) polymorphisms in migraine, we analyzed the APOE genotypes of 241 migraine patients and 587 controls. The results of a Chi-square analysis indicated that APOE alleles were similarly distributed (χ2=2.89, P=0.24) between cases and controls. However, we found a significant (P<0.001) increase of the ε2–ε4 genotype in the group of migraine patients. Patients were divided into three subgroups: migraine with aura; migraine without aura; and mixed headaches (migraine associated with tension-type headache). Subgroup analysis showed that the ε2–ε4 genotype was significantly increased only in patients with mixed headaches. The stratification of patients by APOE status did not reveal significant associations with the clinical features of the disease. In conclusion, we observed no significant association between APOE polymorphisms and migraine. The association between the APOE ε2–ε4 genotype and the tension-type headache deserves further evaluation.

References (19)

There are more references available in the full text version of this article.

Cited by (18)

  • Role of Apolipoprotein E in the tangled mystery of pain

    2018, Medical Hypotheses
    Citation Excerpt :

    Similarly, Cameron et al. (1995) also found that elevated levels of ApoE were found in lumbar pain, spinal pain and peripheral nerve damage patients [17]. In one of the preliminary studies analyzing the relationship between APOE gene variants and migraine, Rainero et al. (2002) failed to ascertain any significant inference between APOE polymorphisms and migraine [83]. In another study evaluating the association of APOE variants, no relation of APOE alleles was found in Australian Caucasian population with the susceptibility of migraine [84].

  • Biomarkers of migraine: Part 1 – Genetic markers

    2016, Journal of the Neurological Sciences
View all citing articles on Scopus
View full text