Protection against Boophilus annulatus infestations in cattle vaccinated with the B. microplus Bm86-containing vaccine Gavac

doi:10.1016/S0264-410X(98)00116-9

Vaccine

Volume 16, Issue 20, December 1998, Pages 1990-1992

https://doi.org/10.1016/S0264-410X(98)00116-9 Get rights and content

Abstract

Tick infestations by Boophilus spp. constitute a major problem for the cattle industry in tropical and subtropical areas of the world. The use of traditional control methods has been only partially successful and tick infestations remain a serious problem. Recently, the gut antigen Bm86 was isolated from B. microplus. Recombinant preparations of this antigen have been used in vaccines for the control of B. microplus infestations. However, in several regions of the world, B. microplus coexists with other Boophilus species, mainly B. annulatus and B. decoloratus. Therefore, there is a need for the simultaneous control of infestations by different Boophilus species. To test the capacity of the P. pastoris-derived Bm86 antigen preparation (Gavac, Heber Biotec S.A., Havana) to control B. annulatus infestations, controlled experiments were conducted in Mexico and Iran. Cattle were vaccinated with Gavac or not vaccinated and then artificially infested with B. annulatus larvae. The results showed for the first time a high protection efficacy (>99.9%) of Gavac in the control of B. annulatus infestations. These results support the application of Bm86-containing vaccines for the control of Boophilus spp. infestations.

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^☆: Gavac is a trademark of Heber Biotec S.A. (P.O. Box 6162, Havana, Cuba)

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Vaccine

Abstract

References (13)

Largescale production in Pichia pastoris of the recombinant vaccine Gavac™ against cattle tick

Vaccine

High level expression of the Boophilus microplus Bm86 antigen in the yeast P. pastoris forming highly immunogenic particle for cattle

J. Biotech.

Effect of vaccination with a recombinant Bm86 antigen preparation on natural infestations of Boophilus microplus in grazing dairy and beef pure and cross-bred cattle in Brazil

Vaccine

Cloning and expression of a protective antigen from cattle tick Boophilus microplus

Prod. Nat. Acad. Sci. USA

Vaccination against ticks

Detection of Bm86 antigen in different strains of Boophilus microplus and effectiveness of immunization with recombinant Bm86

Parasite Immunol.

Cited by (109)

Putative target sites in synganglion for novel ixodid tick control strategies

Ticks and antibodies: May parasite density and tick evasion influence the outcomes following immunization protocols?

Prediction, mapping and validation of tick glutathione S-transferase B-cell epitopes

Rhipicephalus microplus cystatin as a potential cross-protective tick vaccine against Rhipicephalus appendiculatus

Cross protection induced by combined Subolesin-based DNA and protein immunizations against adult Haemaphysalis longicornis

Constituting a glutathione S-transferase-cocktail vaccine against tick infestation

PaperProtection against Boophilus annulatus infestations in cattle vaccinated with the B. microplus Bm86-containing vaccine Gavac☆

Abstract

Vaccine

J. Biotech.

Vaccine

Cloning and expression of a protective antigen from cattle tick Boophilus microplus

Prod. Nat. Acad. Sci. USA

Vaccination against ticks

Detection of Bm86 antigen in different strains of Boophilus microplus and effectiveness of immunization with recombinant Bm86

Parasite Immunol.

Paper
Protection against Boophilus annulatus infestations in cattle vaccinated with the B. microplus Bm86-containing vaccine Gavac☆